{"id":50522,"date":"2025-06-20T12:27:12","date_gmt":"2025-06-20T16:27:12","guid":{"rendered":"https:\/\/www.vielight.com\/?p=50522"},"modified":"2025-08-24T09:35:55","modified_gmt":"2025-08-24T13:35:55","slug":"vielight-neuro-neuromodulation-neurofeedback-tpbm-photobiomodulation","status":"publish","type":"post","link":"https:\/\/www.vielight.com\/blog\/vielight-neuro-neuromodulation-neurofeedback-tpbm-photobiomodulation\/","title":{"rendered":"Vielight Neuro | Randomized Sham-Controlled EEG Neuromodulation itPBM Clinical Study (Brain Photobiomodulation)"},"content":{"rendered":"

Executive summary<\/h2>\n

A randomized, double-blind, sham-controlled, crossover study in healthy older adults showed that a single 20-minute session<\/strong> with the Vielight Neuro Gamma<\/strong> (810 nm LEDs pulsed at 40 Hz) increased alpha\/beta\/gamma power, decreased delta\/theta<\/strong>, and significantly altered functional connectivity and graph-theory network measures<\/strong> (clustering, characteristic path length, local & global efficiency) relative to sham. These findings constitute non-invasive neuromodulation of human brain activity<\/strong> published in a Nature Portfolio journal (Scientific Reports<\/em>).<\/p>\n

Read the full publication here: <\/span><\/span><\/span>Nature<\/span><\/span><\/span><\/a><\/strong><\/span><\/span><\/p>\n

As of Aug 20, 2025, the Vielight Neuro is involved in the only high-level journal publication demonstrating EEG neuromodulation with a\u00a0commercially available, wearable LED<\/strong> brain PBM device.<\/p>\n

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Background: why test tPBM on neural oscillations?<\/h2>\n

Transcranial photobiomodulation (tPBM) uses low-level red\/NIR light to modulate bioenergetic and signaling pathways (e.g., effects on the mitochondrial ETC and cytochrome-c oxidase), with accumulating human evidence in neurology and neurodegeneration. Yet, until this work, direct electrophysiological modulation in humans<\/strong> under rigorous controls had been limited. The study explicitly targeted the default mode network (DMN)<\/strong> with 40 Hz (gamma-range) pulsing<\/strong>, hypothesizing measurable EEG changes.<\/p>\n

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Methods at a glance<\/h2>\n
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Figure 1. Schematic diagram of study design<\/p><\/div>\n