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<\/p>\n\nOther Advantages of the Vielight Vagus<\/h2>\n\n- 100 Hz Pulsing:<\/strong> Aligned with gamma frequencies for cognitive support [Herrmann et al., 2010; Yokota et al., 2022]<\/li>\n<\/ul>\n<\/section>\n\n
Helpful PBM Mechanisms of Action<\/h2>\n\n- Mitochondrial upregulation via cytochrome c oxidase<\/li>\n
- Increased ATP and nitric oxide release<\/li>\n
- Modulation of calcium channels and ion transport<\/li>\n
- Systemic anti-inflammatory effects<\/li>\n<\/ul>\n<\/section>\n\n
Future VNS Applications for PBM Investigation<\/h2>\n\n- HRV and autonomic balance enhancement<\/li>\n
- Stress and anxiety support<\/li>\n<\/ul>\n<\/section>\n\n
Conclusion<\/h2>\n
The Vielight Vagus<\/strong> device introduces a next-generation approach to non-invasive VNS<\/strong>. By combining the benefits of photobiomodulation<\/strong> with cervical vagus nerve stimulation<\/strong>, it offers a safe, comfortable, and effective alternative to traditional VNS methods. Its design supports home-based clinical research<\/strong> and HRV enhancement<\/strong> with minimal user burden. Vielight\u2019s upcoming investigations aim to validate and expand its potential therapeutic applications.<\/p>\n<\/section>\n\nReferences<\/h2>\n\n- Ali, M. S. S., Parastooei, G., Raman, S., Mack, J., Kim, Y. S., & Chung, M. K. (2024). Genetic labeling of the nucleus of tractus solitarius neurons associated with electrical stimulation of the cervical or auricular vagus nerve in mice. Brain stimulation<\/em>, 17<\/em>(5), 987\u20131000.<\/li>\n
- Badran, B. W., et al. (2019). The short and long-term effects of transcutaneous auricular vagus nerve stimulation on heart rate variability in healthy adults: A randomized sham-controlled trial. Brain Stimulation<\/em>, 11(5), 947\u2013955.<\/li>\n
- Benarroch, E. E. (2012). Periaqueductal gray: An interface for behavioral control. Neurology<\/em>, 78(3), 210\u2013217.<\/li>\n
- Bonaz, B., Sinniger, V., & Pellissier, S. (2019). Vagus Nerve Stimulation at the Interface of Brain-Gut Interactions. Cold Spring Harbor perspectives in medicine<\/em>, 9<\/em>(8), a034199.<\/li>\n
- Bremner, J. D., Gurel, N. Z., Jiao, Y., Wittbrodt, M. T., Levantsevych, O. M., \u2026 Pearce, B. D. (2020). Transcutaneous vagal nerve stimulation blocks stress-induced activation of Interleukin-6 and interferon-\u03b3 in posttraumatic stress disorder: A double-blind, randomized, sham-controlled trial. Brain, behavior, & immunity – health<\/em>, 9<\/em>, 100138.<\/li>\n
- Bretherton, B., Atkinson, L., Murray, A., Clancy, J., Deuchars, S. A., & Deuchars, J. (2022). Effects of transcutaneous vagus nerve stimulation on heart rate variability: A systematic review. Frontiers in Neuroscience<\/em>, 16, 913159.<\/li>\n
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- Kreuzer, P. M., Landgrebe, M., Husser, O., Resch, M., Schecklmann, M., Geisreiter, F., … & Langguth, B. (2012). Transcutaneous Vagus Nerve Stimulation: Retrospective Assessment of Cardiac Safety in a Pilot Study. Frontiers in Psychiatry<\/em>, 3, 70.<\/li>\n
- Polak, J. F., et al. (2014). Cervical Vagus Nerve Anatomy in Humans: Implications for Vagus Nerve Stimulation. Pacing and Clinical Electrophysiology<\/em>, 37(6), 765\u2013773.<\/li>\n
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- Silberstein, S. D., Mechtler, L. L., Kudrow, D. B., Calhoun, A. H., McClure, C. K.,… & Yarnitsky, D. (2016). Non-Invasive Vagus Nerve Stimulation for the Acute Treatment of Cluster Headache: Findings From the Randomized, Double-Blind, Sham-Controlled ACT1 Study. Headache<\/em>, 56(8), 1317\u20131332.<\/li>\n
- Sclocco, R., et al. (2019). The influence of respiration on brainstem and cardiovagal response to auricular vagus nerve stimulation: A multimodal ultrahigh-field fMRI study. Brain Stimulation<\/em>, 12(4), 911\u2013921.<\/li>\n
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- Yakunina, N., Kim, S. S., & Nam, E.-C. (2020). Optimization of Transcutaneous Vagus Nerve Stimulation Using Functional MRI. Brain Stimulation<\/em>, 13(3), 734\u2013744.<\/li>\n
- Yan, B., Zhou, J., Yan, F., Gao, M., Tang, J., \u2026 & Luo, Y. (2025). Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications.\u00a0Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism<\/em>, 271678X241311695. Advance online publication.<\/li>\n
- Yokota, H., Edama, M., Hirabayashi, R., Sekine, C., Otsuru, N., Saito, K., Kojima, S., Miyaguchi, S., & Onishi, H. (2022). Effects of Stimulus Frequency, Intensity, and Sex on the Autonomic Response to Transcutaneous Vagus Nerve Stimulation. Brain Sciences<\/em>, 12(8), 1038.<\/li>\n
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- Zhang, Z., Zhang, Z., Liu, P., Xue, X., Zhang, C., \u2026 & Wang, F. (2024). The Role of Photobiomodulation to Modulate Ion Channels in the Nervous System: A Systematic Review.\u00a0Cellular and molecular neurobiology<\/em>,\u00a044<\/em>(1), 79.<\/li>\n
- Zheng, Z. S., Simonian, N., Wang, J., & Rosario, E. R. (2024). Transcutaneous vagus nerve stimulation improves Long COVID symptoms in a female cohort: a pilot study. Frontiers in neurology<\/em>, 15<\/em>, 1393371.<\/li>\n<\/ul>\n<\/section>\n<\/div><\/div><\/div><\/div><\/div>
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![\"\"](\"https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/05\/Vielight-Vagus-PBM-device.jpg\")
<\/h2>\n