{"id":26538,"date":"2022-11-28T16:43:10","date_gmt":"2022-11-28T21:43:10","guid":{"rendered":"https:\/\/www.vielight.com\/?p=26538"},"modified":"2025-10-22T20:59:33","modified_gmt":"2025-10-23T00:59:33","slug":"enhancing-the-default-mode-network","status":"publish","type":"post","link":"https:\/\/www.vielight.com\/blog\/enhancing-the-default-mode-network\/","title":{"rendered":"Enhancing the Default Mode Network (DMN)"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1144px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>Many neuroscience publications indicate that the <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.1510619112?fbclid=IwAR1I8Ofi8Nz7eVKpFhT_a8w7xqgoAHz54UJfXaXixyy6Jrtw3DbmCm7YHms\" target=\"_blank\" rel=\"noopener\">brain is modular<\/a> and composed of different networks <img decoding=\"async\" src=\"https:\/\/static.xx.fbcdn.net\/images\/emoji.php\/v9\/td5\/1.5\/16\/1f9e0.png\" alt=\"\ud83e\udde0\" width=\"16\" height=\"16\" \/><\/p>\n<p>The key to successful brain stimulation (and brain photobiomodulation) is to focus on networks that hold the most importance to your objective.<\/p>\n<p>The Default Mode Network (DMN) is a collection of brain regions that are active when an individual is at rest or not focused on the external environment. Research has linked the DMN to various cognitive functions and mental states, including:<\/p>\n<ol>\n<li><strong>Mind-Wandering and Daydreaming:<\/strong> The DMN is associated with spontaneous thoughts that occur when the mind is not focused on the task at hand. It plays a role in mind-wandering and daydreaming activities.<\/li>\n<li><strong>Self-Referential Thinking:<\/strong> It&#8217;s involved in self-referential thoughts, introspection, and mental simulations about oneself, such as autobiographical memory retrieval, envisioning the future, or contemplating one&#8217;s characteristics and emotions.<\/li>\n<li><strong>Social Cognition:<\/strong> The DMN is implicated in processes related to understanding others&#8217; mental states, empathy, theory of mind (the ability to attribute mental states to oneself and others), and social awareness.<\/li>\n<li><strong>Memory Processing:<\/strong> It plays a role in consolidating memories, particularly those related to personal experiences and episodic memory.<\/li>\n<li><strong>Creative Thinking:<\/strong> Some studies suggest that the DMN is involved in creative thinking processes, as it allows the brain to make connections between different ideas and concepts.<\/li>\n<li><strong>Mental Health Conditions:<\/strong> Dysfunctions in the DMN have been associated with various mental health conditions, including depression, anxiety disorders, schizophrenia, and Alzheimer&#8217;s disease. Changes in the activity or connectivity within the DMN have been observed in individuals with these conditions.<\/li>\n<\/ol>\n<p>Understanding the functions of the DMN provides insights into various aspects of cognition, consciousness, and mental health. However, research in this field is ongoing, and there&#8217;s still much to learn about the exact roles and interactions of the DMN in different cognitive processes and conditions.<\/p>\n<h2>What is the Default Mode Network?<\/h2>\n<div id=\"attachment_26668\" style=\"width: 467px\" class=\"wp-caption alignleft\"><img decoding=\"async\" aria-describedby=\"caption-attachment-26668\" class=\"wp-image-26668\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC.jpg\" alt=\"The Default Mode Network\" width=\"457\" height=\"265\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC-24x14.jpg 24w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC-36x21.jpg 36w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC-48x28.jpg 48w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC-200x116.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC-300x174.jpg 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC-400x232.jpg 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC-500x290.jpg 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC-600x348.jpg 600w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC-700x406.jpg 700w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Default_mode_network-WRNMMC.jpg 709w\" sizes=\"(max-width: 457px) 100vw, 457px\" \/><p id=\"caption-attachment-26668\" class=\"wp-caption-text\">Figure 1 &#8211; Regions of the Default Mode Network<\/p><\/div>\n<p>The Default Mode Network (DMN) is a network of highly interconnected brain regions responsible for internal modes of cognition.<\/p>\n<p>The DMN has been linked to the general health of the brain and is involved in various domains of cognitive and social processing.<\/p>\n<p>The term \u201cdefault\u201d initially arose from the discovery of the network&#8217;s heightened activity during idle periods (aka. when you are not actively thinking), implying that this network is active by default. Since then, additional research has shown this to be a misnomer. The DMN is also active when your brain is engaged in thinking, such as remembering one&#8217;s past or thinking about what might happen in the future.<sup>[41, 42, 43]<\/sup><\/p>\n<p>The DMN includes hubs such as the Medial Prefrontal Cortex (mPFC), the Ventromedial Prefrontal Cortex(vMPFC), the Precuneus, the Inferior Parietal Lobule(IPL), Lateral Temporal Cortex (LTC) and the Posterior cingulate cortex(pCC). Findings from diffusion MRI and resting state fMRI show that neurons in the DMN regions are linked to each other through large tracts of axons and this causes activity in these areas to be correlated with one another. <sup>[22],[23]<\/sup><\/p>\n<h2>The roles of the Default Mode Network<\/h2>\n<p>The Default Mode Network (DMN) plays several crucial roles concerning brain functions. Its roles are linked to what defines us as human beings from a cognitive perspective. It plays several vital tasks in memory functions, imagination, self-referencing, and socializing. Who you are as a person is theorized to be stored within these hubs.<\/p>\n<p><strong><u>The DMN is likely the neurological basis for the self<\/u> <sup>[22]<\/sup><\/strong><\/p>\n<ul>\n<li><em>Autobiographical information<\/em>: Memories of collection of events and facts about one&#8217;s self<\/li>\n<li><em>Self-reference<\/em>: Referring to traits and descriptions of one&#8217;s self<\/li>\n<li><em>Self-emotional state<\/em>: Reflecting about one&#8217;s own emotional state<\/li>\n<\/ul>\n<p><strong><u>Thinking about others<\/u> <sup>[23]<\/sup><\/strong><\/p>\n<ul>\n<li><em>Theory of mind: <\/em>Thinking about the thoughts of others and what they might or might not know<\/li>\n<li><em>Emotions of other: <\/em>Understanding the emotions of other people and empathizing with their feelings<\/li>\n<li><em>Moral reasoning: <\/em>Determining a just and an unjust result of an action<\/li>\n<\/ul>\n<p><strong><u>Remembering the past and thinking about the future<\/u> <sup>[23]<\/sup><\/strong><\/p>\n<ul>\n<li><em>Remembering the past: <\/em>Recalling events that happened in the past<\/li>\n<li><em>Imagining the future: <\/em>Envisioning events that might happen in the future<\/li>\n<li><em>Episodic memory: <\/em>Detailed memory related to specific events in time<\/li>\n<li><em>Story comprehension: <\/em>Understanding and remembering a narrative<\/li>\n<\/ul>\n<\/div><div class=\"fusion-text fusion-text-2\"><h2>The Value of Targeting the Default Mode Network with Pulsed 810nm NIR energy<\/h2>\n<p>Since its discovery, interest has grown in the clinical utility and implications of the DMN. The clinical significance of the DMN has been established or implicated in neurological and neuropsychiatric disorders. Therefore, maintaining the health and improving the performance of the DMN is of particular value. This is why the Vielight Neuro is designed to deliver NIR light transcranially using four diodes targeted at the DMN.<\/p>\n<p>Dysfunction of the DMN has been associated with Alzheimer&#8217;s disease, autism, schizophrenia, depression and other neurologic diseases, \u00a0Parkinson\u2019s, <sup>[25] [26]<\/sup> multiple sclerosis (MS) <sup>[27]<\/sup> and post-traumatic stress disorder (PTSD). <sup>[28]<\/sup> \u00a0Targeting \u00a0the DMN via PBM may therefore be an important therapeutic strategy in the treatment of these diseases. The table below summarizes the research done to date using Vielight technology for various diseases related to the DMN.<\/p>\n<h4 style=\"text-align: center;\"><strong><br \/>\n<span style=\"text-decoration: underline;\">Summary of DMN findings in neurological and neuropsychiatric conditions.<\/span><\/strong><\/h4>\n<table style=\"height: 1207px;\" border=\"1px solid black\" width=\"1243\">\n<tbody>\n<tr>\n<td width=\"104\"><strong>Neurologic Condition<\/strong><\/td>\n<td width=\"236\"><strong>Relation to the DMN<\/strong><\/td>\n<td width=\"283\"><strong>Vielight Photobiomodulation Studies<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"104\">Alzheimer\u2019s Disease<\/td>\n<td width=\"236\">\n<ul>\n<li>Decreased functional connectivity between posterior and anterior portions of the DMN <sup>[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4797836\/#R31\" target=\"_blank\" rel=\"noopener\">31<\/a>]<\/sup><\/li>\n<li>Overlap between the DMN and patterns of amyloid deposits <sup style=\"font-family: inherit;\">[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4797836\/#R38\" target=\"_blank\" rel=\"noopener\">32<\/a>]<\/sup><\/li>\n<\/ul>\n<\/td>\n<td width=\"283\">\n<ul>\n<li>PBM increased connectivity between the posterior cingulate cortex and lateral parietal nodes within the default-mode network in the PBM group. <sup>[36]<\/sup> (<a href=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2020\/01\/Brain_Photobiomodulation_Alzheimers_Chao_2019.pdf\">Link<\/a>)<\/li>\n<li>Significant improvement after 12 weeks of PBM (MMSE,\u00a0<em>p<\/em>\u2009&lt;\u20090.003; ADAS-cog,\u00a0<em>p<\/em>\u2009&lt;\u20090.023). Increased function, better sleep, fewer angry outbursts, less anxiety, and wandering were reported post-PBM. There were no negative side effects.\u00a0<sup>[37]<\/sup> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5568598\/\" target=\"_blank\" rel=\"noopener\">Link<\/a>)<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"104\">Parkinson&#8217;s Disease (AD)<\/td>\n<td width=\"236\">\n<ul>\n<li>Coordinated activity of striatum and the DMN <sup>[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4797836\/#R45\" target=\"_blank\" rel=\"noopener\">33<\/a>]<\/sup><\/li>\n<li>Network disruptions in the DMN and CEN \u2014 heightened activation and dysfunctional connectivity <sup>[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4797836\/#R46\" target=\"_blank\" rel=\"noopener\">34<\/a>]<\/sup><\/li>\n<\/ul>\n<\/td>\n<td width=\"283\">\n<ul>\n<li>Measures of mobility, cognition, dynamic balance and fine motor skill were significantly improved (p &lt; 0.05) with PBM treatment for 12 weeks and up to one year. <sup>[38]<\/sup> (Link)<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"104\">Traumatic Brain Injury<\/td>\n<td width=\"236\">\n<ul>\n<li>DMN connectivity strength predicts emotion recognition and level of social integration in TBI. <sup>[30]<\/sup><\/li>\n<\/ul>\n<\/td>\n<td width=\"283\">\n<ul>\n<li>Increased perfusion in the frontal, temporal, and occipital lobes and the hippocampus after 8 weeks of PBM treatments. <sup>[39]<\/sup> (<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2020.00952\/full\" target=\"_blank\" rel=\"noopener\">Link<\/a>)<\/li>\n<li>Pending publication: Department of Neurology, University of Utah for TBI\/concussion with pro football players. Here is a documentary-style interview with the researchers and participants: <a href=\"https:\/\/www.youtube.com\/watch?v=YTxITq7j9iE&amp;ab_channel=VielightInc\" target=\"_blank\" rel=\"noopener\">https:\/\/www.youtube.com\/watch?v=YTxITq7j9iE&amp;ab_channel=VielightInc<\/a><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"104\">Autism Spectrum Disorder<\/td>\n<td width=\"236\">\n<ul>\n<li>Structural and functional disruptions to key nodes of the DMN, their connectivity with each other, and atypical patterns of connectivity with other brain regions play an important role in the symptomatology of ASD. <sup>[35]<\/sup><\/li>\n<\/ul>\n<\/td>\n<td width=\"283\">\n<ul>\n<li>tPBM was associated with a reduction in ASD severity, as shown by a decrease in CARS scores during the intervention (<em>p<\/em>\u00a0&lt; 0.001). A relevant reduction in noncompliant behavior and in parental stress have been found. Moreover, a reduction in behavioral and cognitive rigidity was reported as well as an improvement in attentional functions and in sleep quality. <sup>[40]<\/sup><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Anatomy of the DMN: roles of the hubs<\/h2>\n<p>The DMN is composed of several hubs that also perform their own individualized tasks.<br \/>\nThis is an introduction to the different hubs of the DMN and what their roles are in the human brain.<\/p>\n<\/div><div class=\"fusion-video fusion-selfhosted-video\" style=\"max-width:100%;\"><div class=\"video-wrapper\"><video playsinline=\"true\" width=\"100%\" style=\"object-fit: cover;\" autoplay=\"true\" muted=\"true\" loop=\"true\" preload=\"auto\" controls=\"1\"><source src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2025\/09\/Vielight-Neuro-Energy-Footprint-Demonstration-Neuro-4-Calvaria.mp4\" type=\"video\/mp4\">Sorry, your browser doesn&#039;t support embedded videos.<\/video><\/div><\/div><div class=\"fusion-text fusion-text-3\"><h4>Medial prefrontal cortex (mPFC)<\/h4>\n<p>The medial prefrontal cortex is located within the brain\u2019s frontal lobe. This region is located behind the forehead.<\/p>\n<div id=\"attachment_26544\" style=\"width: 436px\" class=\"wp-caption alignleft\"><img decoding=\"async\" aria-describedby=\"caption-attachment-26544\" class=\"wp-image-26544\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/prefrontal-cortex-1.jpg\" alt=\"\" width=\"426\" height=\"279\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/prefrontal-cortex-1-24x16.jpg 24w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/prefrontal-cortex-1-36x24.jpg 36w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/prefrontal-cortex-1-48x31.jpg 48w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/prefrontal-cortex-1-200x131.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/prefrontal-cortex-1-300x197.jpg 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/prefrontal-cortex-1-400x262.jpg 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/prefrontal-cortex-1-500x328.jpg 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/prefrontal-cortex-1.jpg 537w\" sizes=\"(max-width: 426px) 100vw, 426px\" \/><p id=\"caption-attachment-26544\" class=\"wp-caption-text\">Figure 2- Prefrontal Cortex<\/p><\/div>\n<p>The medial prefrontal cortex plays a regulatory role in several cognitive functions including attention, inhibitory control, habit formation and working, spatial and long-term memory. <sup>[1]<\/sup><\/p>\n<p>The mPFC is a common region of injury in traumatic brain injury.<\/p>\n<h4><strong>Ventromedial prefrontal cortex (vmPFC)<\/strong><\/h4>\n<p>The ventromedial prefrontal cortex is also located within the brain\u2019s frontal lobe. This region is located right above the eyes and nose.<\/p>\n<p>The ventromedial prefrontal cortex plays a role in decision-making, self-control, and the regulation of emotional responses. <sup>[2, 3]<\/sup><\/p>\n<p>It is also involved in the cognitive evaluation of morality. <sup>[4]<\/sup><\/p>\n<hr \/>\n<h4>Precuneus<\/h4>\n<p>The precuneus is a small section of the superior parietal lobe and it is thought to be the core hub of the DMN. <sup>[9]<\/sup><\/p>\n<p>It is involved in several vital cognitive and visuospatial roles as outlined below.<\/p>\n<div id=\"attachment_26550\" style=\"width: 323px\" class=\"wp-caption alignleft\"><img decoding=\"async\" aria-describedby=\"caption-attachment-26550\" class=\"wp-image-26550\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1.png\" alt=\"\" width=\"313\" height=\"212\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-24x16.png 24w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-36x24.png 36w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-48x32.png 48w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-200x135.png 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-300x203.png 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-400x271.png 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-500x338.png 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-600x406.png 600w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-700x474.png 700w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-768x520.png 768w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-800x541.png 800w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1-1024x693.png 1024w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/precuneus-1-1.png 1058w\" sizes=\"(max-width: 313px) 100vw, 313px\" \/><p id=\"caption-attachment-26550\" class=\"wp-caption-text\">Figure 3 &#8211; Precuneus<\/p><\/div>\n<p>Cognitive roles:<br \/>\n\u2022 Self-consciousness (such as self awareness) <sup>[5]<\/sup><br \/>\n\u2022 Spatial memory (remembering different locations as well as spatial relations between objects) <sup>[6]<\/sup><br \/>\n\u2022 Episodic memory (remembering everyday events) <sup>[7]<\/sup><br \/>\n\u2022 Source memory (remembering the origin of a memory or of knowledge) <sup>[8]<\/sup><\/p>\n<p>Visuospatial:<br \/>\n\u2022 Motor imagery. <sup>[10]\n<\/sup>Motor imagery is used in sport training as mental practice of action, neurological rehabilitation.<br \/>\n\u2022 Motor coordination. <sup>[11]<\/sup><br \/>\nMotor coordination is the orchestrated movement of multiple body parts as required to accomplish intended actions, like running or throwing.<\/p>\n<hr \/>\n<h4>Inferior parietal lobule (IPL)<\/h4>\n<div id=\"attachment_26552\" style=\"width: 218px\" class=\"wp-caption alignleft\"><img decoding=\"async\" aria-describedby=\"caption-attachment-26552\" class=\"wp-image-26552\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/inferior-parietal-lobule-1.png\" alt=\"\" width=\"208\" height=\"208\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/inferior-parietal-lobule-1-24x24.png 24w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/inferior-parietal-lobule-1-36x36.png 36w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/inferior-parietal-lobule-1-48x48.png 48w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/inferior-parietal-lobule-1-66x66.png 66w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/inferior-parietal-lobule-1-100x100.png 100w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/inferior-parietal-lobule-1-150x150.png 150w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/inferior-parietal-lobule-1-200x200.png 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/inferior-parietal-lobule-1-300x300.png 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/inferior-parietal-lobule-1.png 352w\" sizes=\"(max-width: 208px) 100vw, 208px\" \/><p id=\"caption-attachment-26552\" class=\"wp-caption-text\">Figure 4 \u2013 Inferior Parietal Lobule<\/p><\/div>\n<p>The inferior parietal lobule is located on the left and right side of the rear-half of the brain.<\/p>\n<p>The IPL supports some of the most distinctive human mental capacities:<\/p>\n<ul>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Language\" target=\"_blank\" rel=\"noopener\">Language<\/a><\/li>\n<li>Pattern learning<\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Mathematical_operations\" target=\"_blank\" rel=\"noopener\">Mathematical operations<\/a>\u00a0<sup>[12]<\/sup><\/li>\n<li><a title=\"Emotion perception\" href=\"https:\/\/en.wikipedia.org\/wiki\/Emotion_perception\" target=\"_blank\" rel=\"noopener\">Perception of emotions<\/a>\u00a0in facial stimuli<\/li>\n<\/ul>\n<p>The inferior parietal lobe is a foremost convergence zone of diverse mental capacities, several of which are potentially most developed in the human species.<\/p>\n<p>Targeting the IPL with PBM holds great potential to improve cognitive performance in professions that require mathematical or analytical ability.<\/p>\n<hr \/>\n<h4>Posterior cingulate cortex<\/h4>\n<p>The posterior cingulate cortex (pCC) can be found around the midline of the brain.<\/p>\n<p>The pCC forms a central node in the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Default_mode_network\" target=\"_blank\" rel=\"noopener\">default mode network<\/a>\u00a0of the brain.<\/p>\n<div id=\"attachment_26556\" style=\"width: 326px\" class=\"wp-caption alignleft\"><img decoding=\"async\" aria-describedby=\"caption-attachment-26556\" class=\"wp-image-26556\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/posterior-cingulate-cortex-1.jpg\" alt=\"\" width=\"316\" height=\"241\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/posterior-cingulate-cortex-1-24x18.jpg 24w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/posterior-cingulate-cortex-1-36x27.jpg 36w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/posterior-cingulate-cortex-1-48x37.jpg 48w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/posterior-cingulate-cortex-1-200x153.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/posterior-cingulate-cortex-1.jpg 257w\" sizes=\"(max-width: 316px) 100vw, 316px\" \/><p id=\"caption-attachment-26556\" class=\"wp-caption-text\">Figure 5 &#8211; Posterior Cingulate Cortex<\/p><\/div>\n<p>It is highly connected and communicates with various brain networks simultaneously and is involved in diverse functions. <sup>[13]<\/sup><\/p>\n<p>Cerebral blood flow and metabolic rate in the pCC are approximately 40% higher than average across the brain. <sup>[14], [15]<\/sup><\/p>\n<p><strong>Memory <\/strong><\/p>\n<p>The pCC has been linked to:<\/p>\n<ul>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Spatial_memory\" target=\"_blank\" rel=\"noopener\">Spatial memory<\/a> (remembering different locations as well as spatial relations between objects)<\/li>\n<li>Autobiographical memories (autobiographical memory is a memory system consisting of episodes recollected from an individual&#8217;s life)<br \/>\nthe pCC does not show this activity when affected by <a href=\"https:\/\/en.wikipedia.org\/wiki\/Posterior_cingulate#Alzheimer&#039;s_disease\" target=\"_blank\" rel=\"noopener\">Alzheimer&#8217;s Disease<\/a>. <sup>[21]<\/sup><\/li>\n<li>Working memory performance (abnormalities of the ventral pCC is related to a decline) <sup>[17]<\/sup><\/li>\n<\/ul>\n<p>Intrinsic control networks<\/p>\n<p>The pCC has also been strongly implicated as a key part of several intrinsic control networks. <sup>[14], [15]<\/sup><\/p>\n<ul>\n<li>The <a href=\"https:\/\/en.wikipedia.org\/wiki\/Task-positive_network\" target=\"_blank\" rel=\"noopener\">dorsal attention network<\/a>(control of visual attention and eye movement)<\/li>\n<li>The frontoparietal control network (involved in executive motor control). <sup>[14]<\/sup><\/li>\n<\/ul>\n<p>Meditation<\/p>\n<p>The pCC has been found to be activated during self-related thinking and deactivated during meditation and undistracted, effortless mind wandering. <sup>[20]<\/sup> These results track closely with findings about the role of the pCC in the DMN.<\/p>\n<hr \/>\n<h4>Temporal lobes<\/h4>\n<p>The temporal lobes (TL) sit behind the ears and are the second largest lobe.<\/p>\n<div id=\"attachment_26558\" style=\"width: 305px\" class=\"wp-caption alignleft\"><img decoding=\"async\" aria-describedby=\"caption-attachment-26558\" class=\"wp-image-26558\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/temporal-lobes.gif\" alt=\"\" width=\"295\" height=\"295\" \/><p id=\"caption-attachment-26558\" class=\"wp-caption-text\">Figure 6 &#8211; Temporal Lobes<\/p><\/div>\n<p>The TL is involved in processing sensory input for:<\/p>\n<ul>\n<li>Visual processing (complex stimuli such as\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Face_perception\" target=\"_blank\" rel=\"noopener\">faces<\/a> and scenes)<\/li>\n<li>Auditory processing (processes signals from the ears into meaningful units such as speech and words)<\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Language_comprehension\" target=\"_blank\" rel=\"noopener\">Language comprehension<\/a><\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Visual_memory\" target=\"_blank\" rel=\"noopener\">Visual memory<\/a> (<em>visual memory<\/em>is the ability to remember what something looks like)<\/li>\n<\/ul>\n<p>The <span style=\"text-decoration: underline;\">dominant temporal lobe, which is the left side<\/span> in most people, is involved in understanding language and learning and remembering verbal information.<\/p>\n<p>The <span style=\"text-decoration: underline;\">non-dominant lobe, which is typically the right temporal lobe,<\/span> is involved in learning and remembering non-verbal information (e.g. visuo-spatial material and music).<\/p>\n<p>For language learners and musicians, a well-performing temporal lobe plays a crucial role in maximizing performance in these areas.<\/p>\n<hr \/>\n<h4>Hippocampal area<\/h4>\n<p>The hippocampus can be found within the temporal lobes.<\/p>\n<div id=\"attachment_26559\" style=\"width: 314px\" class=\"wp-caption alignleft\"><img decoding=\"async\" aria-describedby=\"caption-attachment-26559\" class=\"wp-image-26559\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1.jpg\" alt=\"\" width=\"304\" height=\"171\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-24x13.jpg 24w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-36x20.jpg 36w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-48x27.jpg 48w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-200x112.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-300x169.jpg 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-400x225.jpg 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-500x281.jpg 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-600x337.jpg 600w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-700x394.jpg 700w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-768x432.jpg 768w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1-800x450.jpg 800w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/hippocampal-area-1.jpg 820w\" sizes=\"(max-width: 304px) 100vw, 304px\" \/><p id=\"caption-attachment-26559\" class=\"wp-caption-text\">Figure 7 &#8211; Hippocampal Area<\/p><\/div>\n<p>The hippocampus plays important roles in the\u00a0formation of:<\/p>\n<ul>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Short-term_memory\" target=\"_blank\" rel=\"noopener\">short-term memory<\/a> to <a href=\"https:\/\/en.wikipedia.org\/wiki\/Long-term_memory\" target=\"_blank\" rel=\"noopener\">long-term memory<\/a><\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Spatial_memory\" target=\"_blank\" rel=\"noopener\">spatial memory <\/a>that enables navigation.<\/li>\n<\/ul>\n<p>In\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Alzheimer%27s_disease\" target=\"_blank\" rel=\"noopener\">Alzheimer&#8217;s disease<\/a>\u00a0(and other forms of\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Dementia\" target=\"_blank\" rel=\"noopener\">dementia<\/a>), the hippocampus is one of the first regions of the brain to suffer damage <sup>[18]<\/sup>\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Short-term_memory\" target=\"_blank\" rel=\"noopener\">short-term memory loss<\/a>\u00a0and\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Disorientation\" target=\"_blank\" rel=\"noopener\">disorientation<\/a>\u00a0are included among the early symptoms.<\/p>\n<p>While a relatively small subregion within the temporal lobes, the hippocampal area plays important roles in memory and is an region of interest in concurrent neurological research.<\/p>\n<hr \/>\n<h2>Conclusion: Engineering pathway for brain photobiomodulation of the DMN<\/h2>\n<p>At Vielight, our thesis behind the Vielight Neuro was to select the DMN and its hubs because of its and their many important roles in human cognitive processes, such as self-awareness, memory, emotions, imagination, mathematical and language processing.<\/p>\n<p>Additionally, through our patented intranasal technology, we are able to reach the vMPFC with pulsed 810nm NIR energy, an advantage that is unique to the Vielight Neuro versus anything else out there.<\/p>\n<p>To read more on the Vielight Neuro&#8217;s design, follow this link: <a href=\"https:\/\/www.vielight.com\/understanding-the-vielight-neuro\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.vielight.com\/understanding-the-vielight-neuro\/<\/a><\/p>\n<p><a href=\"https:\/\/www.vielight.com\/understanding-the-vielight-neuro\/\"><img decoding=\"async\" class=\"alignnone wp-image-26373 size-full\" src=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin.jpg\" alt=\"\" width=\"1549\" height=\"827\" srcset=\"https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-24x13.jpg 24w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-36x19.jpg 36w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-48x26.jpg 48w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-200x107.jpg 200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-300x160.jpg 300w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-400x214.jpg 400w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-500x267.jpg 500w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-600x320.jpg 600w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-700x374.jpg 700w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-768x410.jpg 768w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-800x427.jpg 800w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-1024x547.jpg 1024w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-1200x641.jpg 1200w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin-1536x820.jpg 1536w, https:\/\/www.vielight.com\/wp-content\/uploads\/2022\/11\/Neuro-3-Set-no-PB-8512-fin.jpg 1549w\" sizes=\"(max-width: 1549px) 100vw, 1549px\" \/><\/a><\/p>\n<p><strong>References<\/strong><\/p>\n<ol>\n<li>Jobson DD, Hase Y, Clarkson AN, Kalaria RN. The role of the medial prefrontal cortex in cognition, ageing and dementia. Brain Commun. 2021 Jun 11;3(3):fcab125. doi: 10.1093\/braincomms\/fcab125. PMID: 34222873; PMCID: PMC8249104.<\/li>\n<li>Boes AD, Grafft AH, Joshi C, Chuang NA, Nopoulos P, Anderson SW (December 2011).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3265436\" target=\"_blank\" rel=\"noopener\">&#8220;Behavioral effects of congenital ventromedial prefrontal cortex malformation&#8221;<\/a>.\u00a0<em>BMC Neurology<\/em>.\u00a0<strong>11<\/strong>(151): 151.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1186%2F1471-2377-11-151\" target=\"_blank\" rel=\"noopener\">1186\/1471-2377-11-151<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMC_(identifier)\" target=\"_blank\" rel=\"noopener\">PMC<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3265436\" target=\"_blank\" rel=\"noopener\">3265436<\/a><\/li>\n<li>Bechara A, Tranel D, Damasio H (November 2000).\u00a0<a href=\"https:\/\/doi.org\/10.1093%2Fbrain%2F123.11.2189\" target=\"_blank\" rel=\"noopener\">&#8220;Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions&#8221;<\/a>.\u00a0<em>Brain<\/em>. 123 ( Pt 11) (11): 2189\u2013202.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1093%2Fbrain%2F123.11.2189\" target=\"_blank\" rel=\"noopener\">1093\/brain\/123.11.2189<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMID_(identifier)\" target=\"_blank\" rel=\"noopener\">PMID<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11050020\" target=\"_blank\" rel=\"noopener\">11050020<\/a><\/li>\n<li>Koenigs M, Young L, Adolphs R, Tranel D, Cushman F, Hauser M, Damasio A (April 2007).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2244801\" target=\"_blank\" rel=\"noopener\">&#8220;Damage to the prefrontal cortex increases utilitarian moral judgements&#8221;<\/a>.\u00a0<em>Nature<\/em>.\u00a0<strong>446<\/strong>(7138): 908\u201311.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Bibcode_(identifier)\" target=\"_blank\" rel=\"noopener\">Bibcode<\/a>:<a href=\"https:\/\/ui.adsabs.harvard.edu\/abs\/2007Natur.446..908K\" target=\"_blank\" rel=\"noopener\">446..908K<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1038%2Fnature05631\" target=\"_blank\" rel=\"noopener\">10.1038\/nature05631<\/a><\/li>\n<li>Lou HC, Luber B, Crupain M, Keenan JP, Nowak M, Kjaer TW, Sackeim HA, Lisanby SH (2004).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC404216\" target=\"_blank\" rel=\"noopener\">&#8220;Parietal cortex and representation of the mental Self&#8221;<\/a>.\u00a0<em>Proceedings of the National Academy of Sciences of the United States of America<\/em>.\u00a0<strong>101<\/strong>(17): 6827\u201332.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Bibcode_(identifier)\" target=\"_blank\" rel=\"noopener\">Bibcode<\/a>:<a href=\"https:\/\/ui.adsabs.harvard.edu\/abs\/2004PNAS..101.6827L\" target=\"_blank\" rel=\"noopener\">.101.6827L<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1073%2Fpnas.0400049101\" target=\"_blank\" rel=\"noopener\">10.1073\/pnas.0400049101<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMC_(identifier)\" target=\"_blank\" rel=\"noopener\">PMC<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC404216\" target=\"_blank\" rel=\"noopener\">404216<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMID_(identifier)\" target=\"_blank\" rel=\"noopener\">PMID<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15096584\" target=\"_blank\" rel=\"noopener\">15096584<\/a><\/li>\n<li>Wallentin M, Roepstorff A, Glover R, Burgess N (2006). &#8220;Parallel memory systems for talking about location and age in precuneus, caudate and Broca&#8217;s region&#8221;. NeuroImage. 32 (4): 1850\u201364. CiteSeerX 10.1.1.326.8669. doi:10.1016\/j.neuroimage.2006.05.002. PMID 16828565<\/li>\n<li>Lundstrom BN, Petersson KM, Andersson J, Johansson M, Fransson P, Ingvar M (2003). &#8220;Isolating the retrieval of imagined pictures during episodic memory: activation of the left precuneus and left prefrontal cortex&#8221;. NeuroImage. 20 (4): 1934\u201343. doi:10.1016\/j.neuroimage.2003.07.017. hdl:11858\/00-001M-0000-0013-39A9-E. PMID 14683699<\/li>\n<li>Lundstrom BN, Ingvar M, Petersson KM (2005). &#8220;The role of precuneus and left inferior frontal cortex during source memory episodic retrieval&#8221;. NeuroImage. 27 (4): 824\u201334. doi:10.1016\/j.neuroimage.2005.05.008. hdl:11858\/00-001M-0000-0013-3A7E-4. PMID 15982902<\/li>\n<li>Cavanna AE (2007). &#8220;The precuneus and consciousness&#8221;.\u00a0<em>CNS Spectrums<\/em>.\u00a0<strong>12<\/strong>(7): 545\u201352.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1017%2FS1092852900021295\" target=\"_blank\" rel=\"noopener\">1017\/S1092852900021295<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMID_(identifier)\" target=\"_blank\" rel=\"noopener\">PMID<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17603406\" target=\"_blank\" rel=\"noopener\">17603406<\/a><\/li>\n<li>Cavanna A, Trimble M (2006). &#8220;The precuneus: a review of its functional anatomy and behavioural correlates&#8221;. Brain. 129 (Pt 3): 564\u201383. doi:10.1093\/brain\/awl004. PMID 16399806<\/li>\n<li>Wenderoth N, Debaere F, Sunaert S, Swinnen SP (2005). &#8220;The role of anterior cingulate cortex and precuneus in the coordination of motor behaviour&#8221;.\u00a0<em>Eur J Neurosci<\/em>.\u00a0<strong>22<\/strong>(1): 235\u201346.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1111%2Fj.1460-9568.2005.04176.x\" target=\"_blank\" rel=\"noopener\">1111\/j.1460-9568.2005.04176.x<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMID_(identifier)\" target=\"_blank\" rel=\"noopener\">PMID<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16029213\" target=\"_blank\" rel=\"noopener\">16029213<\/a><\/li>\n<li>Ole Numssen, Danilo Bzdok, Gesa Hartwigsen (2021) Functional specialization within the inferior parietal lobes across cognitive domains eLife 10:e63591 <a href=\"https:\/\/doi.org\/10.7554\/eLife.63591\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.7554\/eLife.63591<\/a><\/li>\n<li>R Leech; R Braga; DJ Sharp (2012).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6621313\" target=\"_blank\" rel=\"noopener\">&#8220;Echoes of the brain within the posterior cingulate cortex&#8221;<\/a>.\u00a0<em>The Journal of Neuroscience<\/em>.\u00a0<strong>32<\/strong>(1): 215\u2013222.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1523%2FJNEUROSCI.3689-11.2012\" target=\"_blank\" rel=\"noopener\">1523\/JNEUROSCI.3689-11.2012<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMC_(identifier)\" target=\"_blank\" rel=\"noopener\">PMC<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6621313\" target=\"_blank\" rel=\"noopener\">6621313<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMID_(identifier)\" target=\"_blank\" rel=\"noopener\">PMID<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22219283\" target=\"_blank\" rel=\"noopener\">22219283<\/a><\/li>\n<li>Leech R, Sharp DJ (July 2013).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3891440\" target=\"_blank\" rel=\"noopener\">&#8220;The role of the posterior cingulate cortex in cognition and disease&#8221;<\/a>.\u00a0<em>Brain<\/em>.\u00a0<strong>137<\/strong>(Pt 1): 12\u201332.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1093%2Fbrain%2Fawt162\" target=\"_blank\" rel=\"noopener\">1093\/brain\/awt162<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMC_(identifier)\" target=\"_blank\" rel=\"noopener\">PMC<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3891440\" target=\"_blank\" rel=\"noopener\">3891440<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMID_(identifier)\" target=\"_blank\" rel=\"noopener\">PMID<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23869106\" target=\"_blank\" rel=\"noopener\">23869106<\/a>.<\/li>\n<li>Pearson, John M.; Heilbronner, Sarah R.; Barack, David L.; Hayden, Benjamin Y.; Platt, Michael L. (April 2011).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3070780\" target=\"_blank\" rel=\"noopener\">&#8220;Posterior cingulate cortex: adapting behavior to a changing world&#8221;<\/a>.\u00a0<em>Trends in Cognitive Sciences<\/em>.\u00a0<strong>15<\/strong>(4): 143\u2013151.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1016%2Fj.tics.2011.02.002\" target=\"_blank\" rel=\"noopener\">1016\/j.tics.2011.02.002<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMC_(identifier)\" target=\"_blank\" rel=\"noopener\">PMC<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3070780\" target=\"_blank\" rel=\"noopener\">3070780<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMID_(identifier)\" target=\"_blank\" rel=\"noopener\">PMID<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21420893\" target=\"_blank\" rel=\"noopener\">21420893<\/a><\/li>\n<li>Maddock, R. J.; A. S. Garrett; M. H. Buonocore (2001). &#8220;Remembering Familiar People: The Posterior Cingulate Cortex and Autobiographical Memory Retrieval&#8221;.\u00a0<em>Neuroscience<\/em>.\u00a0<strong>104<\/strong>(3): 667\u2013676.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/CiteSeerX_(identifier)\" target=\"_blank\" rel=\"noopener\">CiteSeerX<\/a>\u00a0<a href=\"https:\/\/citeseerx.ist.psu.edu\/viewdoc\/summary?doi=10.1.1.397.7614\" target=\"_blank\" rel=\"noopener\">1.1.397.7614<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1016%2Fs0306-4522%2801%2900108-7\" target=\"_blank\" rel=\"noopener\">10.1016\/s0306-4522(01)00108-7<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMID_(identifier)\" target=\"_blank\" rel=\"noopener\">PMID<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11440800\" target=\"_blank\" rel=\"noopener\">11440800<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/S2CID_(identifier)\" target=\"_blank\" rel=\"noopener\">S2CID<\/a>\u00a0<a href=\"https:\/\/api.semanticscholar.org\/CorpusID:15412482\" target=\"_blank\" rel=\"noopener\">15412482<\/a><\/li>\n<li>Kozlovskiy SA, Vartanov AV, Nikonova EY, Pyasik MM, Velichkovsky BM (2012). &#8220;The Cingulate Cortex and Human Memory Processes&#8221;.\u00a0<em>Psychology in Russia: State of the Art<\/em>.\u00a0<strong>5<\/strong>: 231\u2013243.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.11621%2Fpir.2012.0014\" target=\"_blank\" rel=\"noopener\">11621\/pir.2012.0014<\/a><\/li>\n<li>Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, et\u00a0al. (March 2016).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6417794\" target=\"_blank\" rel=\"noopener\">&#8220;Preclinical Alzheimer&#8217;s disease: Definition, natural history, and diagnostic criteria&#8221;<\/a>.\u00a0<em>Alzheimer&#8217;s &amp; Dementia<\/em>.\u00a0<strong>12<\/strong>(3): 292\u2013323.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1016%2Fj.jalz.2016.02.002\" target=\"_blank\" rel=\"noopener\">1016\/j.jalz.2016.02.002<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMC_(identifier)\" target=\"_blank\" rel=\"noopener\">PMC<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6417794\" target=\"_blank\" rel=\"noopener\">6417794<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMID_(identifier)\" target=\"_blank\" rel=\"noopener\">PMID<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27012484\" target=\"_blank\" rel=\"noopener\">27012484<\/a><\/li>\n<li>Smith; Kosslyn (2007). Cognitive Psychology: Mind and Brain. New Jersey: Prentice Hall. pp. 21, 194\u2013199, 349.<\/li>\n<li>Garrison KA, Santoyo JF, Davis JH, Thornhill TA, Kerr CE, Brewer JA (2013).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3734786\" target=\"_blank\" rel=\"noopener\">&#8220;Effortless awareness: using real time neurofeedback to investigate correlates of posterior cingulate cortex activity in meditators&#8217; self-report&#8221;<\/a>.\u00a0<em>Front Hum Neurosci<\/em>.\u00a0<strong>7<\/strong>: 440.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.3389%2Ffnhum.2013.00440\" target=\"_blank\" rel=\"noopener\">3389\/fnhum.2013.00440<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMC_(identifier)\" target=\"_blank\" rel=\"noopener\">PMC<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3734786\" target=\"_blank\" rel=\"noopener\">3734786<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/PMID_(identifier)\" target=\"_blank\" rel=\"noopener\">PMID<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23964222\" target=\"_blank\" rel=\"noopener\">23964222<\/a><\/li>\n<li>Meguro, K. (1999). &#8220;Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET: Implications for Alzheimer&#8217;s disease&#8221;.\u00a0<em>Brain<\/em>.\u00a0<strong>122<\/strong>(8): 1519\u20131531.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Doi_(identifier)\" target=\"_blank\" rel=\"noopener\">doi<\/a>:<a href=\"https:\/\/doi.org\/10.1093%2Fbrain%2F122.8.1519\" target=\"_blank\" rel=\"noopener\">1093\/brain\/122.8.1519<\/a>.\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/ISSN_(identifier)\" target=\"_blank\" rel=\"noopener\">ISSN<\/a>\u00a0<a href=\"https:\/\/www.worldcat.org\/issn\/1460-2156\" target=\"_blank\" rel=\"noopener\">1460-2156<\/a><\/li>\n<li>Andrews-Hanna, Jessica R. (1 June 2012). &#8220;The brain&#8217;s default network and its adaptive role in internal mentation&#8221;. The Neuroscientist. 18 (3): 251\u2013270. doi:10.1177\/1073858411403316. ISSN 1089-4098. PMC 3553600<\/li>\n<li>Horn, Andreas; Ostwald, Dirk; Reisert, Marco; Blankenburg, Felix (2013). &#8220;The structural-functional connectome and the default mode network of the human brain&#8221;. NeuroImage. 102: 142\u2013151. doi:10.1016\/j.neuroimage.2013.09.069. PMID 24099851. S2CID 6455982<\/li>\n<li>Buckner RL, Andrews-HannaJR, Schacter DL (2008). The Brain&#8217;s Default Network: Anatomy, Function, and Relevance to Diseas. Annals of the New York Academy of Sciences. 1124 (1): 1\u201338.<\/li>\n<li>Van Eimeren T, Monchi O, Ballanger B, Strafella AP (2009). Dysfunction of the Default Mode Network in Parkinson Disease: A Functional Magnetic Resonance Imaging Study. Arch Neurol. 2009 July ; 66(7): 877\u2013883.<\/li>\n<li>Tessitore A, Esposito F, Vitale C, Santangelo G, Amboni M, Russo A, Corbo D, Cirillo G, Barone P, Tedeschi G (2012). Default-mode network connectivity in cognitively unimpaired patients with Parkinson disease. Neurology. 79(23):2226-32.<\/li>\n<li>Rocca MA, Valsasina P, Absinta M, Riccitelli G, Rodegher ME, Misci P, Rossi P, Falini A, Comi G, Filippi M (2010). Default-mode network dysfunction and cognitive impairment in progressive MS. Neurology. 74(16):1252-9.<\/li>\n<li>Judith K. Daniels, PhD, Paul Frewen, PhD, Margaret C. McKinnon, PhD, and Ruth A. Lanius (2011). Default mode alterations in posttraumatic stress disorder related to early-life trauma: a developmental perspective. J Psychiatry Neurosci. 2011 Jan; 36(1): 56\u201359<\/li>\n<li>Mohan A, Roberto AJ, Mohan A, Lorenzo A, Jones K, Carney MJ, Liogier-Weyback L, Hwang S, Lapidus KA. The Significance of the Default Mode Network (DMN) in Neurological and Neuropsychiatric Disorders: A Review. Yale J Biol Med. 2016 Mar 24;89(1):49-57. PMID: 27505016; PMCID: PMC4797836.<\/li>\n<li>Lancaster Katie, Venkatesan Umesh M., Lengenfelder Jean, Genova Helen M., Default Mode Network Connectivity Predicts Emotion Recognition and Social Integration After Traumatic Brain Injury, Frontiers in Neurology 10, 2019, <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2019.00825,DOI=10.3389\/fneur.2019.00825\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2019.00825,DOI=10.3389\/fneur.2019.00825<\/a>, ISSN:1664-2295<\/li>\n<li>Hafkemeijer A, van der Grond J, Rombouts SA. Imaging the default mode network in aging and dementia.\u00a0<em>Biochim Biophys Acta.\u00a0<\/em>2012;1822(3):431\u2013441<\/li>\n<li>Mormino EC, Smiljic A, Hayenga AO, Onami SH, Greicius MD, Rabinovici GD. et al. Relationships between beta-amyloid and functional connectivity in different components of the default mode network in aging.\u00a0<em>Cereb Cortex.\u00a0<\/em>2011;21(10):2399\u20132407.<\/li>\n<li>Kwak Y, Peltier S, Bohnen NI, M\u00fcller ML, Dayalu P, Seidler RD. Altered resting state cortico-striatal connectivity in mild to moderate stage Parkinson\u2019s disease.\u00a0<em>Front Syst Neurosci.\u00a0<\/em>2010;4:143<\/li>\n<li>Putcha D, Ross RS, Cronin-Golomb A, Janes AC, Stern CE. Altered intrinsic functional coupling between core neurocognitive networks in Parkinson\u2019s disease.\u00a0<em>Neuroimage Clin.\u00a0<\/em>2015;7:449\u2013455.<\/li>\n<li>Padmanabhan A, Lynch CJ, Schaer M, Menon V. The Default Mode Network in Autism. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Sep;2(6):476-486. doi: 10.1016\/j.bpsc.2017.04.004. PMID: 29034353; PMCID: PMC5635856.<\/li>\n<li>Chao LL. Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial. Photobiomodul Photomed Laser Surg. 2019 Mar;37(3):133-141. doi: 10.1089\/photob.2018.4555. Epub 2019 Feb 13. PMID: 31050950.<\/li>\n<li>Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Photomed Laser Surg. 2017 Aug;35(8):432-441. doi: 10.1089\/pho.2016.4227. Epub 2017 Feb 10. PMID: 28186867; PMCID: PMC5568598.<\/li>\n<li>Liebert A, Bicknell B, Laakso EL, Heller G, Jalilitabaei P, Tilley S, Mitrofanis J, Kiat H. Improvements in clinical signs of Parkinson&#8217;s disease using photobiomodulation: a prospective proof-of-concept study. BMC Neurol. 2021 Jul 2;21(1):256. doi: 10.1186\/s12883-021-02248-y. PMID: 34215216; PMCID: PMC8249215.<\/li>\n<li>Chao Linda, Barlow Cody, Karimpoor Mahta, Lim Lew, Changes in Brain Function and Structure After Self-Administered Home Photobiomodulation Treatment in a Concussion Case, Frontiers in Neurology, 11, 2020, https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2020.00952<\/li>\n<li>Pallanti S, Di Ponzio M, Grassi E, Vannini G, Cauli G. Transcranial Photobiomodulation for the Treatment of Children with Autism Spectrum Disorder (ASD): A Retrospective Study.\u00a0<em>Children<\/em>. 2022; 9(5):755. https:\/\/doi.org\/10.3390\/children9050755<\/li>\n<li>Andreasen NC., O&#8217;Leary DS., Cizadlo T., Arndt S., Rezai K. Remembering the past: two facets of episodic memory explored with positron emission tomography.\u00a0<span class=\"ref-journal\"><em>Am J Psychiatry.<\/em>\u00a0<\/span>1995;<span class=\"ref-vol\">152<\/span>:1576\u20131585.\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7485619\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Am+J+Psychiatry.&amp;title=Remembering+the+past:+two+facets+of+episodic+memory+explored+with+positron+emission+tomography.&amp;author=NC.+Andreasen&amp;author=DS.+O%27Leary&amp;author=T.+Cizadlo&amp;author=S.+Arndt&amp;author=K.+Rezai&amp;volume=152&amp;publication_year=1995&amp;pages=1576-1585&amp;pmid=7485619&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google Scholar<\/a>]<\/span><\/li>\n<li>Buckner RL., Carroll DC. Self-projection and the brain.\u00a0<span class=\"ref-journal\"><em>Trends Cogn Sci.<\/em>\u00a0<\/span>2007;<span class=\"ref-vol\">11<\/span>:49\u201357.\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17188554\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=Trends+Cogn+Sci.&amp;title=Self-projection+and+the+brain.&amp;author=RL.+Buckner&amp;author=DC.+Carroll&amp;volume=11&amp;publication_year=2007&amp;pages=49-57&amp;pmid=17188554&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google Scholar<\/a>]<\/span><\/li>\n<li>Spreng RN., Mar RA., Kim AS. The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis.\u00a0<span class=\"ref-journal\"><em>J Cogn Neurosci.<\/em>\u00a0<\/span>2009;<span class=\"ref-vol\">21<\/span>:489\u2013510.\u00a0[<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18510452\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>]\u00a0<span class=\"nowrap\">[<a role=\"button\" href=\"https:\/\/scholar.google.com\/scholar_lookup?journal=J+Cogn+Neurosci.&amp;title=The+common+neural+basis+of+autobiographical+memory,+prospection,+navigation,+theory+of+mind,+and+the+default+mode:+a+quantitative+meta-analysis.&amp;author=RN.+Spreng&amp;author=RA.+Mar&amp;author=AS.+Kim&amp;volume=21&amp;publication_year=2009&amp;pages=489-510&amp;pmid=18510452&amp;\" target=\"_blank\" rel=\"noopener noreferrer\" aria-expanded=\"false\" aria-haspopup=\"true\">Google Scholar<\/a>]<\/span><\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":36678,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"_acf_changed":false,"bwfblock_default_font":"","inline_featured_image":false,"mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[478,477,2998],"tags":[],"class_list":["post-26538","post","type-post","status-publish","format-image","has-post-thumbnail","hentry","category-blog","category-biohacking","category-education","post_format-post-format-image"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/posts\/26538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/comments?post=26538"}],"version-history":[{"count":0,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/posts\/26538\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/media\/36678"}],"wp:attachment":[{"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/media?parent=26538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/categories?post=26538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vielight.com\/wp-json\/wp\/v2\/tags?post=26538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}