1. Ein wachsendes Problem für ältere Menschen – altersbedingter kognitiver Abbau
2. Verschiedene Faktoren der Gehirnalterung und des altersbedingten kognitiven Verfalls
3. Photobiomodulation des Gehirns (PBM) und Mitochondrienfunktion
4. PBM im Gehirn und metabolische Effekte
5. PBM im Gehirn und entzündungshemmende Wirkungen
6. PBM im Gehirn führt zu einer Verringerung der neuronalen Exzitotoxizität
7. PBM im Gehirn erhöht die zerebrale Vaskularität und Sauerstoffversorgung
8. Veröffentlichte Forschung – PBM im Gehirn bei älteren Menschen

Ein wachsendes Problem für ältere Menschen ist der altersbedingte kognitive Abbau.

Aufgrund des medizinisch-technischen Fortschritts ist die ältere Bevölkerung das am schnellsten wachsende Segment der Weltbevölkerung. Folglich sind die Nebenwirkungen des natürlichen altersbedingten kognitiven Verfalls – wie verlangsamtes Denken, Gedächtnisverlust und geringe geistige Energie – aufgrund der wachsenden Zahl älterer Menschen und der negativen qualitativen Auswirkungen auf ihre Lebensqualität ein immer häufiger auftretendes Problem.

Source: United Nations, Department of Economic and Social Affairs, Population Division (2019). World Population Prospects 2019.

Andererseits haben die Fortschritte in der Hirnstimulationsforschung in Verbindung mit technologischen Innovationen die Neurotechnologie für Langlebigkeit (oder Anti-Aging) zu einem vielversprechenden Vorschlag für das 21.

Es stellt sich die Frage: Wie kann die Photobiomodulation des Gehirns als Biohacking-Tool für Langlebigkeit eingesetzt werden, um die negativen Auswirkungen der Gehirnalterung teilweise zu mildern, indem bestimmte physiologische Prozesse verstärkt werden?

In diesem Artikel werden wir uns auf veröffentlichte Forschungsstudien beziehen, um zu untersuchen, wie die Photobiomodulation des Gehirns für Langlebigkeit und Anti-Aging eingesetzt werden könnte, indem die neuronale mitochondriale Funktion und die allgemeine ganzheitliche Gehirnleistung verbessert werden.

Bitte beachten Sie, dass nichts Bekanntes die genetische Alterung und ihre negativen Auswirkungen rückgängig machen kann, aber der Lebensstil und technologische Interventionen haben das Potenzial, einige der negativen Auswirkungen des Alterns zu verringern oder abzuschwächen.

Verschiedene Faktoren der Gehirnalterung und des altersbedingten kognitiven Abbaus

Die Alterung des Gehirns ist ein natürlicher biologischer Prozess, der zu einem Rückgang der physiologischen Funktionen des Gehirns führt. Mehrere Faktoren tragen zu diesem Phänomen bei.

Einer der bemerkenswerten Faktoren der Hirnalterung ist ein allmählicher Rückgang der Mitochondrienfunktion in den Neuronen. Dies führt zu einem Rückgang der kognitiven Funktionen und einer suboptimalen Gehirnleistung, da der Energiestoffwechsel der Neuronen in den Mitochondrien abnimmt.

Darüber hinaus führt eine Verringerung der Hirndurchblutung und der Sauerstoffversorgung des Gehirns aufgrund eines Verlusts der Hirnvaskularität zu einem Rückgang der kognitiven Funktion[19].

Das alternde Gehirn ist auch durch eine zunehmende Neuroinflammation gekennzeichnet.[17] Wissenschaftler haben Neuroinflammation mit kognitivem Abbau und einem höheren Risiko für altersbedingte kognitive Beeinträchtigungen in Verbindung gebracht.[18]

Was sind Mitochondrien und Neuronen?

• Mitochondrien sind die Batterien der Zelle. Diese membrangebundenen Zellorganellen (Mitochondrium, Singular) erzeugen den Großteil der chemischen Energie, die für die biochemischen Reaktionen der Zelle benötigt wird. Die von den Mitochondrien erzeugte chemische Energie wird in einem kleinen Molekül namens Adenosintriphosphat (ATP) gespeichert.
• Neuronen sind Informationsübermittler. Neuronen, manchmal auch Nervenzellen genannt, machen etwa 10 Prozent des Gehirns aus; der Rest besteht aus Gliazellen und Astrozyten, die die Neuronen unterstützen und ernähren. Sie nutzen elektrische Impulse und chemische Signale, um Informationen zwischen verschiedenen Bereichen des Gehirns sowie zwischen dem Gehirn und dem übrigen Nervensystem zu übermitteln.

Konzentration auf neuronale Mitochondrien und den Alterungsprozess

Neuronale Mitochondrien spielen eine Schlüsselrolle bei der Regulierung des Alterungsprozesses des Gehirns. Wenn ihre Funktion nachlässt, wird die Produktion von Adenosintriphosphat (ATP) reduziert, was zu einer Verringerung des neuronalen Stoffwechsels führt. Darüber hinaus führt ein Rückgang der Mitochondrienfunktion zu einer verminderten Aktivierung von Signalwegen und Transkriptionsfaktoren, die die Expression verschiedener Proteine modulieren[1].

Hinweis: Transkriptionsfaktoren regulieren die Transkription von Genen – den Prozess des Kopierens in RNA während der Proteinsynthese (kurze Information: mindestens 10.000 verschiedene Proteine machen Sie zu dem, was Sie sind und halten Sie in diesem Zustand). Proteine sind die Bausteine dessen, was Sie sind.

Photobiomodulation des Gehirns und Mitochondrienfunktion

Die Photobiomodulation des Gehirns birgt das Potenzial, die Funktion der Mitochondrien zu verbessern und so die negativen Auswirkungen des Alterns teilweise zu mildern.

Der Mechanismus der Photobiomodulation (PBM) beruht auf der Fähigkeit der Zellen, Photonen des roten bis nahen Infrarotlichts (620-1100 nm) durch den Photoakzeptor der Mitochondrien, die Cytochrom-c-Oxidase (CCO), zu absorbieren[2].

Anmerkung: CCO ist der vierte Enzymkomplex der mitochondrialen Atmungskette und katalysiert die Reaktion, bei der Sauerstoff zu Wasser reduziert wird, was mit der Produktion von Stoffwechselenergie in den Zellen verbunden ist.

Figure 1: Activation of mitochondria cytochrome c oxidase through photobiomodulation

Die mitochondrialen Biomechanismen der Photobiomodulation

CCO-Aufregulierung

Die Absorption von roten bis NIR-Photonen durch die Mitochondrien CCO löst eine Reihe von zellulären und physiologischen Effekten im Gehirn aus, die auch als CCO-Hochregulierung bekannt sind.

Figure 2: The cascade effects of photobiomodulation

Die Hochregulierung von CCO führt zu:

• Ein geringer Anstieg reaktiver Sauerstoffspezies (ROS), die mitochondriale Signalwege aktivieren, die mit der Neuroprotektion verbunden sind. [3]
• Ein Anstieg von Stickstoffmonoxid (NO), das die Vasodilatation und den zerebralen Blutfluss stimuliert [4].
• Eine Erhöhung der ATP-Produktion [5].

Zusammengenommen lösen diese Effekte die Aktivierung von Signalwegen und Transkriptionsfaktoren aus, die die langfristige Expression verschiedener Proteine und Stoffwechselwege im Gehirn modulieren[6]. Darüber hinaus wurden durch PBM bei älteren Menschen auch elektrophysiologische Effekte auf das menschliche Gehirn nachgewiesen[7, 8].

Metabolische Auswirkungen und Sauerstoffversorgung des Gehirns

Die metabolischen Wirkungen der PBM bei älteren Menschen erhöhen nachweislich den zerebralen Blutfluss (CBF) aufgrund der gesteigerten CCO-Aktivität, was zu einer verbesserten Sauerstoffversorgung des Gehirns führt. Die Photobiomodulation des präfrontalen Kortex konnte die Alpha-, Beta- und Gamma-Leistung des EEG im Ruhezustand erhöhen und eine effizientere präfrontale fMRI-Reaktion bewirken, was die kognitive Verarbeitung bei älteren Menschen erleichtert. [8] Darüber hinaus hat sich gezeigt, dass die Photobiomodulation des Default Mode Network (DMN) die zerebrale Durchblutung aufgrund einer erhöhten Mitochondrienaktivität verbessert. [9]

PBM im Gehirn und entzündungshemmende Wirkung

Zusätzlich zu den oben genannten Erkenntnissen könnte die PBM aufgrund ihrer entzündungshemmenden Wirkung eine vielversprechende Strategie zur Verbesserung alternder Gehirne sein. [10, 11]

PBM im Gehirn führt zu einer Verringerung der neuronalen Exzitotoxizität

Im Jahr 2022 veröffentlichten Forscher der University of Alberta eine vielschichtige Studie, in der sie die Art und Weise untersuchten, wie lebende Zellen, zelluläre Strukturen und Komponenten wie Mikrotubuli und Tubulin auf Nahinfrarot-Photobiomodulation (NIR PBM) unter Verwendung des Vielight Neuro Alpha reagieren.

Ihre Studie zeigte, dass die PBM ein Gleichgewicht zwischen Erregungsstimulation und -hemmung herstellt, was darauf hindeutet, dass die PBM die Exzitotoxizität verringern kann, was für die Erhaltung eines gesunden Gehirns von Bedeutung ist. Diese Studie zeigte auch, dass die PBM mit niedriger Intensität das mitochondriale Potenzial hochreguliert und die physiologischen Gehirnfunktionen verbessert, die aufgrund von Traumata oder Neurodegeneration beeinträchtigt sind. [14]

PBM im Gehirn erhöht die zerebrale Vaskularität und Sauerstoffversorgung

Der Alterungsprozess geht mit Veränderungen der Gewebestruktur einher, die häufig zu einem Funktionsverlust führen. Die Blutgefäße des Gehirns bilden dabei keine Ausnahme. Mit zunehmendem Alter nimmt die Durchblutung des Gehirns durch den Verlust der zerebralen Gefäße ab, was zu einem kognitiven Verfall führt, wenn die Neuronen nicht mehr ausreichend mit Sauerstoff versorgt werden können.[21] Die Photobiomodulation des Gehirns erhöht nachweislich die zerebrale Durchblutung aufgrund der Vasodilatation, die nach der Freisetzung von Stickstoffmonoxid auftritt.[20]

Figure 3: The beneficial effects of photobiomodulation

Zusammenfassung

Diese Ergebnisse sind vielversprechend, denn mit zunehmendem Alter nimmt die Mitochondrienfunktion ab, die Hirndurchblutung und die Sauerstoffversorgung nehmen ab[12] , Entzündungen nehmen zu und die Vaskularität des Gehirns nimmt ab.

Die Photobiomodulation des Gehirns hat jedoch das Potenzial, die Mitochondrienfunktion, die Hirndurchblutung und die Vaskularität des Gehirns teilweise zu verbessern und möglicherweise auch Entzündungen zu verringern.

Veröffentlichte Forschung – PBM des Gehirns bei älteren Menschen

Im Jahr 2017 fanden Forscher der Abteilung für Psychologie und des Instituts für Neurowissenschaften der University of Texas in Austin heraus, dass die Photobiomodulation des Gehirns die Alpha-, Beta- und Gamma-Leistung des EEG im Ruhezustand erhöht, eine effizientere fMRT-Aktivität fördert und die kognitive Verarbeitung von Verhaltensweisen bei Erwachsenen mittleren Alters und älteren Menschen mit dem Risiko eines kognitiven Verfalls erleichtert. Es wurden keine unerwünschten Wirkungen berichtet.

Diese Ergebnisse unterstützen das Potenzial der Photobiomodulation des Gehirns zur Verbesserung der neurokognitiven Funktionen und zur Bekämpfung des altersbedingten und durch Gefäßkrankheiten verursachten kognitiven Verfalls [13].

Im Jahr 2019 führte Dr. Chao vom Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, eine Studie an Patienten im Alter von 80 Jahren durch, bei denen Demenz diagnostiziert wurde. Die NIR-PBM-Behandlungen wurden von einem Studienpartner zu Hause dreimal pro Woche mit dem Vielight Neuro Gamma-Gerät durchgeführt. Nach 12 Wochen kam es in der PBM-Gruppe zu Verbesserungen bei den ADAS-cog- und NPI-Scores, zu einer erhöhten zerebralen Durchblutung und zu einer verbesserten Konnektivität zwischen dem posterioren cingulären Kortex und den lateralen parietalen Knoten innerhalb des Default-Mode-Netzwerks. [15]

Im Jahr 2021 entdeckten Forscher der School of Medical Sciences der Universität Sydney in einer Pilotstudie mit 12 Teilnehmern, dass Messungen der Mobilität, der Kognition, des dynamischen Gleichgewichts und der Feinmotorik durch eine PBM-Behandlung über 12 Wochen und bis zu einem Jahr signifikant verbessert wurden. Viele individuelle Verbesserungen lagen über dem minimalen klinisch bedeutsamen Unterschied, dem Schwellenwert, der für die Teilnehmer als bedeutsam erachtet wird. Die individuellen Verbesserungen variierten, aber viele hielten bis zu einem Jahr an, wenn die Behandlung mit dem Vielight Neuro Gamma zu Hause fortgesetzt wurde. Es gab einen nachweisbaren Hawthorne-Effekt, der unterhalb des Behandlungseffekts lag. Es wurden keine Nebenwirkungen der Behandlung beobachtet.

References

1. Jang, J. Y., Blum, A., Liu, J., & Finkel, T. (2018). The role of mitochondria in aging. The Journal of clinical investigation, 128(9), 3662–3670. https://doi.org/10.1172/JCI120842
2. Dompe, C., Moncrieff, L., Matys, J., Grzech-Leśniak, K., Kocherova, I., Bryja, A., Bruska, M., Dominiak, M., Mozdziak, P., Skiba, T., Shibli, J. A., Angelova Volponi, A., Kempisty, B., & Dyszkiewicz-Konwińska, M. (2020). Photobiomodulation-Underlying Mechanism and Clinical Applications. Journal of clinical medicine, 9(6), 1724. https://doi.org/10.3390/jcm9061724
3. Suski, J. M., Lebiedzinska, M., Bonora, M., Pinton, P., Duszynski, J., & Wieckowski, M. R. (2012). Relation between mitochondrial membrane potential and ROS formation. In Mitochondrial bioenergetics (pp. 183-205). Humana Press.
4. Wang X., Tian F., Soni S.S., Gonzalez-Lima F., Liu H. Interplay between up-regulation of cytochrome-c-oxidase and hemoglobin oxygenation induced by near-infrared laser. Sci. Rep. 2016;6:30540. doi: 10.1038/srep30540.
5. Hamblin M.R. Photobiomodulation for traumatic brain injury and stroke. J. Neurosci. Res. 2018;96:731–743. doi: 10.1002/jnr.24190.
6. Cardoso FDS, Mansur FCB, Lopes-Martins RÁB, Gonzalez-Lima F, Gomes da Silva S. Transcranial Laser Photobiomodulation Improves Intracellular Signaling Linked to Cell Survival, Memory and Glucose Metabolism in the Aged Brain: A Preliminary Study. Front Cell Neurosci. 2021 Sep 3;15:683127. doi: 10.3389/fncel.2021.683127. PMID: 34539346; PMCID: PMC8446546.
7. Wang, X., Dmochowski, J. P., Zeng, L., Kallioniemi, E., Husain, M., GonzalezLima, F., & Liu, H. (2019). Transcranial photobiomodulation with 1064-nm laser modulates brain electroencephalogram rhythms. Neurophotonics, 6(2), 025013.
8. Vargas E, Barrett DW, Saucedo CL, et al. Beneficial neurocognitive effects of transcranial laser in older adults. Lasers in medical science. 2017;32(5):1153–1162. [PubMed: 28466195]
9. Chao LL. Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial. Photobiomodul Photomed Laser Surg. 2019 Mar;37(3):133-141. doi: 10.1089/photob.2018.4555. Epub 2019 Feb 13. PMID: 31050950.
10. Hamblin MR. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys. 2017;4(3):337-361. doi: 10.3934/biophy.2017.3.337. Epub 2017 May 19. PMID: 28748217; PMCID: PMC5523874.
11. dos Santos Cardoso, F., Mansur, F.C.B., Araújo, B.H.S. et al.Photobiomodulation Improves the Inflammatory Response and Intracellular Signaling Proteins Linked to Vascular Function and Cell Survival in the Brain of Aged Rats. Mol Neurobiol 59, 420–428 (2022). https://doi.org/10.1007/s12035-021-02606-4
12. Braz, I. D., & Fisher, J. P. (2016). The impact of age on cerebral perfusion, oxygenation and metabolism during exercise in humans. The Journal of physiology, 594(16), 4471–4483. https://doi.org/10.1113/JP271081
13. Vargas E, Barrett DW, Saucedo CL, Huang LD, Abraham JA, Tanaka H, Haley AP, Gonzalez-Lima F. Beneficial neurocognitive effects of transcranial laser in older adults. Lasers Med Sci. 2017 Jul;32(5):1153-1162. doi: 10.1007/s10103-017-2221-y. Epub 2017 May 2. PMID: 28466195; PMCID: PMC6802936.
14. Staelens Michael, Di Gregorio Elisabetta, Kalra Aarat P., Le Hoa T., Hosseinkhah Nazanin, Karimpoor Mahroo, Lim Lew, Tuszyński Jack A. Near-Infrared Photobiomodulation of Living Cells, Tubulin, and Microtubules In Vitro, Frontiers in Medical Technology 4. 2022 May 04, https://doi.org/10.3389/fmedt.2022.871196, ISBN:2673-3129
15. Chao LL. Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial. Photobiomodul Photomed Laser Surg. 2019 Mar;37(3):133-141. doi: 10.1089/photob.2018.4555. Epub 2019 Feb 13. PMID: 31050950.
16. Liebert A, Bicknell B, Laakso EL, Heller G, Jalilitabaei P, Tilley S, Mitrofanis J, Kiat H. Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study. BMC Neurol. 2021 Jul 2;21(1):256. doi: 10.1186/s12883-021-02248-y. PMID: 34215216; PMCID: PMC8249215.
17. Sparkman NL, Johnson RW. Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation. 2008;15(4-6):323-30. doi: 10.1159/000156474. Epub 2008 Nov 26. PMID: 19047808; PMCID: PMC2704383.
18. Simen AA, Bordner KA, Martin MP, Moy LA, Barry LC. Cognitive dysfunction with aging and the role of inflammation. Ther Adv Chronic Dis. 2011 May;2(3):175-95. doi: 10.1177/2040622311399145. PMID: 23251749; PMCID: PMC3513880.
19. Yang T, Sun Y, Lu Z, Leak RK, Zhang F. The impact of cerebrovascular aging on vascular cognitive impairment and dementia. Ageing Res Rev. 2017 Mar;34:15-29. doi: 10.1016/j.arr.2016.09.007. Epub 2016 Sep 28. PMID: 27693240; PMCID: PMC5250548.
20. Salgado AS, Zângaro RA, Parreira RB, Kerppers II. The effects of transcranial LED therapy (TCLT) on cerebral blood flow in the elderly women. Lasers in medical science. 2015;30(1):339– 346. doi: 10.1007/s10103-014-1669-2 [PubMed: 25277249]
21. Yang T, Sun Y, Lu Z, Leak RK, Zhang F. The impact of cerebrovascular aging on vascular cognitive impairment and dementia. Ageing Res Rev. 2017 Mar;34:15-29. doi: 10.1016/j.arr.2016.09.007. Epub 2016 Sep 28. PMID: 27693240; PMCID: PMC5250548.

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X-Plus 3 Components

The X-Plus 3 consists of 4 main modules: the X-Plus Head module, the X-Plus Body module, and 2 633nm X-Plus nasal applicators.

The X-Plus Head Module

In everyday life and in sports, your visual processing ability, balance, and coordination is crucial. The X-Plus Head module sits comfortably on the occipital lobe and cerebellum, which are the areas of the brain that process these tasks.

The occipital lobe interprets information from the eyes and turns it into the world as a person sees it. It is responsible for visuospatial processing, distance, and depth perception. ^[1].

The cerebellum is another important structure of the brain.

Although the cerebellum accounts for approximately 10% of the brain’s volume, it contains over 50% of the total number of neurons in the brain. The cerebellum is involved in the following functions:

Maintenance of balance and posture. The cerebellum is important for making postural adjustments to maintain balance. It modulates commands to motor neurons to compensate for shifts in body position or changes in load upon muscles. ^[2]

Coordination of voluntary movements. Most movements are composed of different muscle groups acting together in a temporally coordinated fashion. One major function of the cerebellum is to coordinate the timing and force of these different muscle groups to produce fluid limb or body movements.[3]

Motor learning. The cerebellum is important for motor learning. The cerebellum plays a major role in adapting and fine-tuning motor programs to make accurate movements through a trial-and-error process (e.g. learning to hit a baseball or throwing a basketball accurately).^[4]

Combined, the cerebellum and occipital lobe account for much of the brain’s processing ability for movements required for physical performance. Now imagine the ability to stimulate these two brain structures to improve your everyday life and boost athletic and sports performance in a convenient manner without side effects.

X-Plus Intranasal module

The nasal cavity is saturated with blood capillaries. Five major arteries connect directly to the circulatory system ^[5], making it the perfect location for systemic photobiomodulation.

The X-Plus 3 comes with two 633nm intranasal modules, enabling photobiomodulation of the blood capillary-rich nasal passageway. Additionally, our patented clip-on intranasal design enables usage almost anywhere and while on the move.

Why systemic circulation?

Intranasal photobiomodulation improves oxygenation and leads to increased adenosine triphosphate (ATP) levels in various tissues. ^[6]

Light energy absorbed by blood through the photobiomodulation process leads to an increase in nitric oxide (NO) release.^[7]

Nitric oxide is one of the most important factors affecting microcirculation. This leads to increases in vasodilation which contributes to improved oxygen delivery to tissues , which is important for optimizing your health and sports performance.

The result of light-induced photodissociation of oxyhemoglobin also results in a significant enrichment of local tissue oxygenation. ^[8]

The systemic effect of photobiomodulation on circulation could be a consequence of positive alterations in the membrane properties of red blood cells (RBCs). Absorption of red/NIR light affects hydrogen bonds, which could induce structural changes in RBC membrane proteins. ^[9]

This in turn, results in an improvement of RBC structure, ATP content, and osmotic properties. ^[10]

Conclusively, the X-Plus 3 intranasal modules are powerful tools for internalizing photobiomodulation into your circulatory system.

The X-Plus Body module

We hypothesize that the X-Plus Body module could potentially help with the immune system when positioned on the sternum. A version of this has been used in our clinical trial to treat COVID-19, and the findings will be made public soon.

Clinical trial link: Link

Additionally, the X-Plus Body module can be positioned over joints and certain body parts, such as the shoulder or knees to provide anti-inflammatory relief.

Conclusion

The X-Plus 3 is a useful device for improving anyone’s quality of life, but an especially powerful tool for athletes and biohackers to maximize performance. In a competitive world where the smallest difference in mental and physical performance can mean either first place or everything else after, the X-Plus 3 is a powerful tool to try.

References

[1] – Rehman A, Al Khalili Y. Neuroanatomy, Occipital Lobe. [Updated 2021 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK544320/

[2, 3, 4] – Cerebellum (section 3, Chapter 5) neuroscience online: An electronic textbook for the Neurosciences: Department of Neurobiology and Anatomy – the University of Texas Medical School at Houston. Cerebellum (Section 3, Chapter 5) Neuroscience Online: An Electronic Textbook for the Neurosciences | Department of Neurobiology and Anatomy – The University of Texas Medical School at Houston. (n.d.). Retrieved February 20, 2022, from https://nba.uth.tmc.edu/neuroscience/m/s3/chapter05.html#:~:text=The%20cerebellum%20is%20important%20for,in%20order%20to%20maintain%20balance.&text=One%20major%20function%20of%20the,is%20important%20for%20motor%20learning.

[5] – Nguyen JD, Duong H. Anatomy, Head and Neck, Lateral Nasal Artery. [Updated 2021 Nov 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK546681/

[6], [7] – Lohr NL, Keszler A, Pratt P, Bienengraber M, Warltier DC, Hogg N. Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection. J Mol Cell Cardiol. 2009 Aug;47(2):256-63. doi: 10.1016/j.yjmcc.2009.03.009. Epub 2009 Mar 25. PMID: 19328206; PMCID: PMC4329292.

[8] – Stadler I, Evans R, Kolb B, Naim JO, Narayan V, Buehner N, Lanzafame RJ. In vitro effects of low-level laser irradiation at 660 nm on peripheral blood lymphocytes. Lasers Surg Med. 2000;27(3):255-61. doi: 10.1002/1096-9101(2000)27:3<255::aid-lsm7>3.0.co;2-l. PMID: 11013387.

[9] – Szymborska-Małek K, Komorowska M, Gąsior-Głogowska M. Effects of Near Infrared Radiation on DNA. DLS and ATR-FTIR Study. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jan 5;188:258-267. doi: 10.1016/j.saa.2017.07.004. Epub 2017 Jul 12. PMID: 28723592.

[10] – Walski T, Dyrda A, Dzik M, Chludzińska L, Tomków T, Mehl J, Detyna J, Gałecka K, Witkiewicz W, Komorowska M. Near infrared light induces post-translational modifications of human red blood cell proteins. Photochem Photobiol Sci. 2015 Nov;14(11):2035-45. doi: 10.1039/c5pp00203f. PMID: 26329012.

The post X-Plus 3: Exponential Performance first appeared on Vielight Inc - Deutsch.

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Personal wellness has become a very hot subject over the last decade. The majority of interest in this subject area is focused on physical wellness, mostly of the body. Thankfully, more and more people are realizing the importance of brain wellness. There is a growing interest in maintaining a healthy brain and cognitive “sharpness.”  The latter refers to mental or cognitive acuity.

Thus, there is more and more buzz about such subjects as cognitive or mental acuity. Brain performance, cognitive vitality and general brain wellness are becoming more commonplace subjects of interest to larger audiences. What used to be the domain of biohackers is rapidly moving into mainstream.

Everyone likes to feel good and to be sharp. Maintaining healthy brain function is imperative, if you’re going to remain competitive and competent in the workplace, business, sports and creative endeavors. It is no less important in personal aspects of life and in supporting good quality of life overall. If you want to be sharp, you need to take care of your cognitive acuity.

What is Mental Acuity, or is it Cognitive Acuity? (Potato — Pot[a]to)

The terms mental acuity and cognitive acuity refer to the same functions and abilities of the human brain. Therefore, they are two different ways to name the same thing. While mental acuity is a more commonly used term, cognitive acuity is the preferred term in the scientific community.

Cognitive or mental acuity is one of those terms that everyone seems to understand, but few really know what it actually means. So, what exactly is cognitive acuity? Let’s shed some light on this subject and define it.

If you were to search for “cognitive acuity” on Google, you would quickly notice that there isn’t a great deal of information available on the subject. That’s because cognitive acuity isn’t a thing in and of itself. Instead, it’s a cluster of mental processes that we, as humans, rely on for optimal brain function and performance. Consequently, cognitive acuity refers to the following brain functions:

Information processing

Memory storage

Attention

Situational judgement

Information Processing

Your brain’s capacity to process information is its most important function. The brain has the ability to store, manipulate, and record information that you gather from your environment. You need to be able to sort through all that information in order to make sound and logical decisions with speed and accuracy. (Loftus, G. 2019. Human Memory: The Processing of Information). This process of “sorting” is called information processing and is a major factor contributing to cognitive acuity.

Memory Storage

Your ability to store memories is directly related to your ability to process sensory information. In your everyday life, you are constantly bombarded by various forms of information. You have a great deal of visual information coming in, along with auditory and sensory information (touch, taste, and smell).

Your brain needs to discern which information is relevant and important, and which information should be ignored. Relevant information is further processed into memories, and that isn’t an easy process. Memory storage, whether it’s short-term or long-term memory, is fraught with problems.

Recording and storing memories depends on our capacity to process information quickly and accurately. All information processing in a human brain is fallible to a certain extent. Inevitably, some information gets lost or distorted, as it is coded into a memory. Efficient memory storage relies on sound information processing and on an efficient attentional system. (Loftus, G. 2019. Human Memory: The Processing of Information).

Attention

Attention is the brain’s ability to focus on one task or a single sensory stimulus. More importantly, the brain does it despite the presence of other sensory stimuli competing for your attention. The ability to pick out one thing from your environment and apply concentrated focus to it is a special ability. It is also an ability that can be improved with training.

Most people find it hard to do two things at the same time. Dividing your attention can lead to performance errors and faulty memory coding. To enhance cognitive acuity, it’s best to avoid distractions and practice focused attention. Such practice will improve your brain’s information processing and allow you to have more effective situational judgement: a skill that is crucial for problem solving. (Pashler, H. 2016. Attentional Limitations in Dual-task Performance).

Situational Judgement

According to Peter Leeds, a Behavioral Scientist from the University of Baltimore, effective cognitive or mental acuity plays a direct role in our ability to detect the correct response in any given situation. Making sound decisions that have optimal outcomes is a very important and desired skill. The capacity to make sound decisions depends upon the ability to pay attention to the sensory information coming in and judging how to choose the right response.

Situational judgement is particularly important in fast-paced environments, where split-second decision making is required. This quality relies on the other skills associated with cognitive acuity, specifically, information processing, memory, and attention, as discussed above. (Leeds, P. 2017. Behavior Research Methods).

Speed and accuracy of the brain response and information processing
as a measure of cognitive or mental acuity

To reiterate, cognitive or mental acuity is effectively a measure of the brain’s ability to respond to a stimulus. It accounts for the speed of a response and the quality and relevance of the response. Oftentimes, such measures of response are defined in layman terms as the “sharpness” of the human mind.

To assess an individual’s state of cognitive acuity, one would need to measure the speed of the individual’s brain responses. This can be done on biochemical and biophysical levels, which are very complex processes.

Alternatively, the speed of the brain response can be measured by cognitive tests. These specialized tests examine a number of factors relevant to cognitive or mental acuity. More specifically, these factors can be broken down to responses associated with cognitive focus and concentration, memory, and understanding. In measuring these four categories, it is possible to assess how well the brain performs relative to a benchmark or a baseline.

The sharpness of mind — the speed and the quality of brain responses

We can break down these factors further and add clarity to the definitions, as well as to the subject mater itself. Let’s take a look at what constitutes the speed and the quality of responses, as well as the sharpness of the mind.

It is important to note that cognitive or mental acuity can have an effect on intellectual abilities of an individual. However, although it can affect one’s ability to retrieve knowledge, it does not constitute a measure of one’s intellectual capacity. In more simple terms, the assessment of your mental acuity does not measure how smart you are.

Mental acuity and intellectual capacity: crystalized and fluid intelligence

Thus, cognitive acuity has to do with some of the aspects of brain’s physiological functions affecting fluid intelligence. Fluid intelligence refers to the ability to reason and think flexibly, and to solve problems. Information processing and situational judgement are the factors that support this category.

Mental acuity has less to do with longer-term intellectual capacity, although it can influence crystalized intelligence. Crystallized intelligence refers to the accumulation of knowledge, facts, and skills that are acquired throughout life and the ability to recall and use that knowledge. Memory storage, as discussed earlier, is a relevant factor for this category.

How do benchmarks and baselines help to measure cognitive acuity?

Benchmarks themselves can represent the brain’s capacity to perform a specific task in a given state. For example, there are benchmarks to help estimate cognitive acuity of a healthy brain. Other benchmarks allow assessment of the current state of individual’s mental acuity based on the brain with abnormal functions.

Such abnormalities can range from very mild, to heavily pronounced or severe. The former can occur when a person is tired, for example. The latter can be seen in individuals with complex neurodegenerative disorders. People with neurodegenerative diseases, like Alzheimer’s Disease and other dementias, score very poorly on cognitive acuity tests. As a result, the more progressed the disease is, the lower is the score on the cognitive acuity test.

Fluctuations in cognitive acuity and cognitive vitality

Individuals with healthy brains can experience drops in the levels of their cognitive acuity. This can happen due to exhaustion, fatigue, stress or illness, among other factors. Such fluctuations in cognitive acuity can be recorded reasonably easily by way of analysis using standardised testing and personal benchmarking.

The records of such analysis can help individuals to better understand what leads to declines in their cognitive acuity. Knowing the cause can help to eliminate or avoid it. If neither is possible, one can elect a therapy to remedy the effects of such cause on the brain and on cognitive acuity.

What is important in assessing cognitive acuity and cognitive vitality?

The reason benchmarks and baselines are important is because they help to assess an individual’s cognitive acuity based on relevant criteria. Numerous factors can be of consideration in establishing the appropriateness of cognitive acuity tests. Thus, age, level of physical fitness and activity, diet and other lifestyle factors can influence cognitive (mental) acuity.

For example, it would make little sense to assess the normal state of mental acuity of an average sixty-year-old and an average sixteen-year-old based on exactly the same criteria. However, some criteria can and will overlap in different age groups, although, the expected performance benchmarks will be different.

How does age affect cognitive acuity?

Studies and empirical data show that, on average, an individual adult’s cognitive acuity deteriorates with age. Notably, numerous factors like lifestyle and diet, fitness and general health can contribute to fluctuations, changes and declines in cognitive acuity.

On average, as is the case with all organs, the brain’s ability to perform its tasks and duties usually deteriorates over time. Therefore, older people are more susceptible to deficiencies in cognitive acuity. Manifestations of such deficiencies can include forgetfulness, decreasing ability to focus and more.

Many of you have heard or even used the phrase, “I am not as sharp as I used to be.” It is a colloquial expression that often refers to a recognition of a decline in mental acuity with age. Importantly, it points to the fact that an individual is capable of recognizing such a decline on his or her own.

What factors contribute to a decline in cognitive acuity?

Numerous factors can contribute to a decline in mental acuity. Among them are environmental factors, lifestyle factors, circadian rhythm factors, factors related to blood oxygenation and blood circulation, genetic factors, and drug-related factors.

Environmental factors

The factors affecting cognitive acuity and cognitive vitality can be environmental, like air and water quality, and exposure to sunlight. Numerous studies support this hypothesis.

Lifestyle factors

The factors affecting cognitive acuity can be personal lifestyle-related factors like physical activity, diet, education, professional and leisure activities.

Duration and quality of sleep also contribute to cognitive acuity and cognitive vitality. The actual effect of lifestyle factors on cognitive vitality remains a subject of ongoing studies and debates. (Arthur F. Kramer et al, 2004, Environmental Influences on Cognitive and Brain Plasticity During Aging).

Blood circulation and blood oxygenation effects on mental acuity

Poor blood circulation and blood oxygenation can be contributing factors to declines in cognitive (mental) acuity. They can also be effects of an unhealthy lifestyle and poor dietary choices. If you are concerned with your blood circulation and blood oxygenation, it may be a good time to reassess your lifestyle. You can make healthier choices and pay more careful attention to your physical activity routine and your diet.

Circadian rhythms factors

Activity-rest patterns and circadian rhythms can contribute to the variations in mental acuity. Circadian rhythms are regulatory cycles in the brain. They manage your alertness and sleepiness on 24-hour cycles. Your brain will react to changes in the environment based on this 24-hour circadian rhythm cycle. This is a very important and complex regulatory mechanism that developed in mammals over a long period of time.

If your circadian rhythm is off, it may not trigger timely and appropriate responses to the environmental changes from your brain. Thus, you may suffer from insufficient sleep and poor physical recovery, further inhibiting your mental acuity.

Genetic factors

Moreover, genetic factors can play an important role in changes in cognitive or mental acuity and cognitive vitality. If you have dementia or neurodegenerative diseases somewhere in your family tree, you may be more susceptible to such disorders. It is hardly possible to change genetic predispositions, at least at this point in time. However, healthy lifestyle choices may help to decrease the probability of or postpone the onset of neurological disorders.

Drugs related factors

As well, some drugs, both medical and illegal, can be contributors to your mental acuity decline. Various illegal drags can have detrimental effects on your brain’s ability to function normally, and, therefore, on your mental acuity.

Unfortunately, some prescription medications can also have negative effects on your mental acuity. Most commonly, these could occur as side effects of a medication. It is prudent to speak to your physician about the possible side effects and dangers of the medications that you are taking. You can also inquire about remedies to help to mitigate such side effects.

Curiously, some of the contributing factors can also be those that can help to mitigate the changes in mental acuity. This can be possible because an individual can make changes to some of those factors. For example, you can improve your diet, sleep more, exercise better, and the list goes on. These facts have prompted growth of new movements that advocate and promote healthy and natural wellness choices. Biohacking is one of them, and it is gaining popularity worldwide.

New Neuro Modulation Technology Can Help to Improve Mental Acuity

As attention to brain wellness and mental acuity has grown, so has innovation in the space of brain wellness technology. Creative minds in science and technology are cooperating to develop new tools to help you take better care of your brain. Non-invasive neuro modulation is one area of such research and cooperation, and improving mental acuity is one of its goals.

Creative new technologies utilize light, sound, electromagnetic energy and visual stimuli to stimulate your brain. Moreover, new wearable and smart devices can help train your brain and to improve your mental acuity. Some of them are non-invasive and have no side effects. This is only the beginning of a new era of personal neuro-modulation technology for home use. Stay tuned for more.

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Vielight with its photobiomodulation (PBM) technology, has been the subject of growing interest in the field of biohacking of the brain. The delivery of light to influence brain functions is appealing to many biohackers. Not surprisingly, most are seeking ways to achieve that in an uncomplicated and affordable way, without the risk of known side effects. For these reasons, Vielight’s method of delivering light to the brain in a non-invasive way is garnering great interest and support from clinicians, researchers and consumers. This is reflected in growing online and offline forums and discussions. The subjects of discussions and interest are the many possibilities of using Vielight devices for applications that have been considered difficult to achieve.

The recent Biohacker Summit 2019, held in Helsinki, Finland, on 1 and 2 of November 2019, manifested what excites biohackers. Notably, a big excitement was about the novel approach of the application and use of PBM by Vielight. Thus, the presence of Vielight among the exhibitors created a lively buzz in the air. Not surprisingly, there also was a very dynamic stream of visitors to our busy booth. Many visitors were turning up at the booth due to the word-of-mouth recommendations by users of Vielight devices. Interestingly, many visitors were meditators of various levels who were curious about improving their meditative experiences. As a result, the interest grew much bigger after the Vielight Founder & CEO, Dr. Lew Lim made a stage presentation entitled “Elevating Brain Performance with Light”.

How Photobiomodulation Influences Body and Brain Functions?

According to Dr. Lim, “Published research has shown that photobiomodulation (PBM) has clear influence on body and brain functions. The influence of PBM is significant – all the way from cell activity to high level performance outcomes. We continue to learn from these research results and extend the theories to their effects on humans by supporting clinical trials.

Evidently, biohackers now recognize that evidence clearly shows that the brain responds to PBM, if it is delivered to the brain in the right way. In this regard, we published data to show the effects of pulsing light of 40 Hz (Gamma), when it is applied to the brain. The light causes elevation of the power of alpha, beta and gamma oscillations and reduction of the power of the slow delta and theta. Alternatively, when we induce 10 Hz (Alpha) pulsation, significant response is largely observed in the alpha band. Overall, these findings show that the brain can respond differently to different pulse rates.

Consequently, Vielight has plans for further investigation in brain response. One day, we will be able to individualize intervention, so that the brain will be given the best boost for optimal function via PBM. Now, that would be a biohacker’s dream.”

Vielight Returns to TransTech 2019

The TransTech Conference 2019 will be held again on November 15-16, 2019 at Palo Alto, California. It is a conference where futuristic ideas in transformative technologies are exchanged. This is an area that Vielight identifies with. Dr. Lew Lim will be speaking on “Brain Photobiomodulation Advances”. He will update the attendees on the state of PBM as a brain stimulation and modulation method. Importantly, Vielight will also have a booth where attendees are welcome to visit and learn more about the Vielight devices. Furthermore, visitors will have the opportunity to speak with Vielight researchers, Dr. Alison Smith and Dr. Mahta Karimpoor, and experience the devices.

Vielight Makes its Presence in Europe at MEDICA

For the first time, Vielight will be exhibiting at the MEDICA Trade Show in Dusseldorf, Germany. The event will be held on November 18-21, 2019. Most notably, MEDICA is the largest medical product and services trade show in the world. This year more than 125,000 visitors and more than 5,000 exhibitors are expected. There has been a growing interest in Vielight devices in Europe. Thus, Vielight product experts, Gennady Lemud and Dominic Lim, are looking forward to introducing our products at the Vielight booth G40 at Hall 13.

Dr. Lew Lim to Speak in Perth, Western Australia

Dr. Lew Lim will be giving a talk in Perth, Australia at a special event, on November 26^th 2019, from 11 am to 2 pm, at the Institute of Functional Neuroscience. His talk is titled “Photobiomodulation for Extraordinary Brain Functions”. Further information about the talk can be found at: https://www.facebook.com/events/1762789687199309/. Dr. Lim explains, “We are unearthing new information on how extraordinary brain functions can be achieved with light. I hope to share our experiences and research and to make this event a very rewarding one for attendees.”

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On March 21, 2019, pharmaceutical giants Biogen and Eisai announced they were discontinuing their much-anticipated clinical trial. It was the final phase of one of the most promising Alzheimer’s Disease drugs under trials, aducanumab. This announcement was heart-breaking for those who had been holding out for it. There is no other promising drug entering late-phase trials for the next few years.

Another blow to the search for a cure for Alzheimer was made on March 27, 2019. A special advisory panel appointed by the FDA unanimously rejected Neuronix’s non-pharmaceutical effort. It involved a combination of repetitive transcranial magnetic stimulation (rTMS) and brain training to treat Alzheimer.
So, is there any hope for the millions of Alzheimer’s sufferers?

Beneath the Noise

Beneath the noise and conundrum, Vielight has been quietly developing a novel solution with the Vielight Neuro RX Gamma. Just recently, in March 2019, the journal, Photobiomodulation, Photomedicine and Laser Surgery published landmark findings by the University of California at San Francisco’s Linda Chao. Prof. Chao’s controlled study reported significant cognitive improvements in dementia patients. Furthermore, for the first time, clear improvements in blood perfusion and functional connectivity were shown by fMRI imaging. Her paper, “Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Functions, Cerebral Perfusion, and Resting State Functional Connectivity in Patients with Dementia: A Pilot Study” is a validation of a paper published earlier, “Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report” (Saltmarche et al, 2017).

The significance of the recovery observed in the human subjects in these studies were unprecedented. Vielight is now heading towards the second phase of a pilot study, and this month, expect to start a multi-site pivotal study in an attempt to validate these findings.

A Light in the Dark Tunnel of Alzheimer’s Research

“It is a single intervention with multiple pathways in its mechanisms, equivalent to many drugs working at the same time. The Vielight Neuro RX Gamma fires up the body’s natural intelligence to restore systemic homeostasis — a process that corrects functional aberrances that may have caused this disease.”

There is now a light at the end of the dark tunnel of Alzheimer research. “The field of Alzheimer research is a graveyard of high-profile failures, flooring some of the biggest pharmaceutical companies and many great scientific minds in medical research,” reflects Dr. Lew Lim, Founder & CEO of Vielight. “Because we are a small company in this field taking on a goliath-sized task, it is understandable why our efforts have not been accorded the widespread recognition. However, finding a solution may not require hundreds of millions of dollars. What matters is hard reproducible scientific evidence. It could come from a new modality with a different theoretical basis — photobiomodulation as delivered by Vielight. It is a single intervention with multiple pathways in its mechanisms, equivalent to many drugs working at the same time. The Vielight Neuro RX Gamma fires up the body’s natural intelligence to restore systemic homeostasis — a process that corrects functional aberrances that may have caused this disease.”

Vielight to Participate in the Paleo f(x) 2019
International Conference and Expo

Paleo f(x) 2019 is a large biohacking event taking place in Austin, Texas from April 26 to 28. It is also the world largest gathering of Paleo, ancestral health, keto, functional medicine and strength and conditioning experts.

Attendees can find Vielight at the booth #7. There they can learn about the potential of Vielight tech for improving the functions of the brain and the body. Using photobiomodulation, the Vielight technology offers a safe, simple and non-invasive way for improvement in general wellness.

Vielight to Present at the BFE Conference

For the first time, Vielight will showcase its technology at the Biofeedback Federation of Europe (BFE) annual conference. The BFE takes place from April 9 to 13 in Cardiff, Wales, U.K. Dr. Lew Lim is a speaker at the Photobiomodulation Symposium and will present on April 11 from 17:45 to 18:15. His presentation is titled “New Discoveries in Transcranial Photobiomodulation for Neurofeedback”. Among other speakers are Dr. Margaret Naeser, Research Professor of Neurology at Boston University, and Penijean Gracefire, an innovation leader in neurofeedback.

“This is the first time that photobiomodulation is featured in a biofeedback or neurofeedback conference,” said Dr. Lew Lim. “The recognition reflects the growing interest in this science. Particularly of importance is how it can profoundly accelerate the desired outcomes in neurofeedback treatments. Attendees at the conference may go home with new ideas on how to help their patients and themselves better.”

Vielight will also be demonstrating real-time brain response through the manipulation of the parameters using the Neuro Pro device prototype.

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The article is titled “Can Brain-Machine Interfaces Put You In A Better Mood?”. Read it here – Link

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Top Biohacker Positions Vielight Neuro as a New Brain-boosting Nootropic

“Photobiomodulation may be the answer that biohackers have been searching for as a technological alternative to smart drugs and nootropics. According to Ben Greenfield, “the use of light to stimulate the brain is effective, significant and without the worries of major side effects.” Greenfield is a world-renowned fitness guru, author, competitive triathlete and trend-setting biohacker and has a lot of experience with PBM and biohacking.

In his latest blog article, Ben Greenfield continues:
“Everyone understands that the brain is the command center of all our functions. We are truly dead only when the brain is dead. We are at our peak when our brain is at its peak. At the elite level of sports performance, the difference between winning and losing depends on the mental state.

Needless to say, success or failure in life is largely contingent upon the quality of one’s cognitive or mental state. Hence, the value of being able to improve brain health and performance, which explains the growing interest in the tools to do this, especially so-called “nootropics”.

So, we experiment with brain exercises, meditation and mindfulness, natural substances such as magic mushrooms and ayahuasca, synthetics such as Modafinil/Provigil, Piracetam/Racetams, along with ADHD medications such as Adderall and Ritalin.

Admittedly, there are reliable cases of these chemical substances helping to enhance mental performance (although controlled empirical studies have questioned these on larger controlled studies). However, all of them have some reported forms of side effects, many quite serious, if consumption is not controlled.

One of my favorite such methods – photobiomodulation for the head.”

Furthermore, Greenfield notes the Vielight Neuro Alpha and Gamma models as the devices that he uses for brain photobiomodulation.

China NeuroConf 2019

At the beginning of January 2019, a small group from our team, led by our founder, Dr. Lew Lim, headed for China. There, in the city of Sanya, the 5th Neurology and Neurosurgery Conference, NeuroConf 2019, took place. Dr. Lim presented his work on the potential of the application of brain photobiomodulation (PBM) in the treatment of Alzheimer’s Disease.

The audience of primarily neurologists, neurosurgeons and neuroscientists, mostly from China, found the presentation interesting and informative. With a deep-rooted history of traditional Chinese medicine, Chinese scientists have a strong interest in leaning on natural medicine. Many locally developed alternative treatment therapies employ herbal and natural remedies. Thus, presenting photobiomodulation as a therapeutic modality for the treatment of Alzheimer’s disease was of interest to this group.

As always, Dr. Lim is spreading his passion for non-invasive light therapy and brain photobiomodulation modalities. This was a conference that helped to advance the cause.

Over the years, Chinese and Russian scientists studied the effects of blood photobiomodulation by introducing a laser beam intravenously. Thus, the concept is not completely new to Chinese scientists. However, the application of PBM in the treatment of dementia, and Alzheimer’s in particular, was novel and worthy of attention.

So far, this trip and presentation were only some of the initial steps in introducing Vielight technology to new markets internationally. We have a long road ahead, and we are eager to confront and overcome all the challenges lying before us.

International Brian Stimulation Conference 

In the end of February 2019, a group of Vielighters is going to head to beautiful British Columbia. The reason is the International Brain Stimulation Conference that takes place in Vancouver. With Dr. Lim as their leader, our Vielighters have planned an exciting presentation for the attendees of the conference. The title and the subject of this presentation are “Impactful and Easy Brain Stimulation with Photobiomodulation”.

The Vielight team presentation will take place on Wednesday, February 27, 2019 between 7:30 AM and 8:30 AM. This will be an hour filled with interesting scientific and anecdotal data based on various research, customer feedback and Dr. Lim’s personal experience and technical knowledge.

If you are also planning to attend the International Brain Stimulation Conference in Vancouver this year, do find your way to the Vielight presentation and say hello. You can contact Dr. Mahta Karimpoor at mahta.karimpoor@vielight.com for further information and to register.

Blood Photobiomodulation Developments for 2019

Many of our supporters, customers and advocates are aware of the opportunities and challenges in the space of blood photobiomodulation. Over the last couple of years our focus on brain PBM took precedence inside the Vielight offices. However, we plan that in 2019 we’ll manage to dedicate more time to research and development related to blood PBM.

We are pushing the envelop in PBM research and development. This is what we love to do. However, doing it at the intersection of science, engineering and economics is a challenge that only the most devoted can pass. We trust that we are on the right path, have the appropriate attitude and possess the right knowledge. All those critical success factors make us capable of perseverance.

Our devices, Vielight 633 and Vielight 655, which provide an opportunity to self-administer intranasal systemic photobiomodualtion therapy, are gaining popularity. Furthermore, new research from various sources around the world unlocks support about the benefits of this form of light therapy. Some recent scientific papers present additional data on the applications of blood PBM as an alternative treatment modality for a number of pathologies. They show the diverse range of possible applications from general wellness to very specific health anomalies. We are looking forward to digging deeper into this important and much needed field of PBM.

The post Good Beginning for Our Year of Photobiomodulation 2019 first appeared on Vielight Inc - Deutsch.

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The Vielight X-Plus Design

The Vielight X-Plus’ design and flexibility enables the user to deliver photobiomodulation (PBM) to areas not already covered by other Vielight devices. In general, the new device is very versatile.  The light source is a single 810 nm LED, emitting near infrared light (NIR). A flexible stainless steel band holds the NIR LED  in place, creating a simple yet effective headset. The new design allows for an easy irradiation of the posterior brain areas, such as the cerebellum.

Similar to existing Neuro headsets, the X-Plus comes with its own 633 nm intranasal applicator for blood irradiation. The 633 nm wavelength complements the 810 nm wavelength of the Neuro Alpha and Neuro Gamma. By delivering PBM to the capillary network for circulation throughout the body, this theoretically increases blood oxygenation and decreases blood viscosity – we are planning research in this area.

Combining Vielight Neuros

Furthermore, the new X-Plus is usable on its own and in combination with other Vielight Neuro devices. It can be used consecutively and even at the same time with the Vielight Neuro Alpha and Gamma models. Thus, when used  for brain PBM, the X-Plus complements the Neuro models. It can deliver light energy to a brain area that is not accessible by the Neuros. Notably, the X-Plus design incorporates an extra long steel band. This long and flexible band permits the placement of this devices on top and over the Neuro headsets. Although both, the Alpha and the Gamma, already deliver strong outcomes, the addition of the X-Plus makes photobiomodulation process more holistic.

Additionally, the X-Plus is suitable for photobiomodulation on other parts of the body. The flexibility of the metal band and functional design of this wearable device permit users to place it in a number of positions. Thus, it is convenient to use in a number of areas, from head to toe.

How and Why the Vielight X-Plus was Developed?

Principally, the Vielight X-Plus was developed to tackle the following questions:

How do we conveniently direct near infrared (NIR) light to the cerebellum and brain stem?
What could we do to complement our existing brain irradiation wearable’s line up?
How can we conveniently direct NIR to any location on the body such as the thymus gland, the gut and the vagus nerve, among others?

The X-Plus’ design and functionality provide solid answers to all of these questions. Its posterior LED module can reach areas that the Neuro headsets cannot. At present, the Neuro Alpha and Gamma devices only deliver NIR light to the hubs of the default mode network of the brain. The X-Plus covers an additional area, the posterior brain area, which when used in combination with the Neuro, effectively covers all the essential areas of the brain. If you have been following the reporting of our clinical trials and studies, you have probably read about their applications and related methodologies, the X-Plus was designed to improve on and expand on the applications.

Further, in the answer to the last question above, the X-Plus is adoptable to numerous other placements on the body, as we noted above. Such versatility provides a functional and effective way of delivering PBM to areas where other Veilight devices do not reach. Just like its predecessors Neuro Alpha and Gamma, the X-Plus is effectively a headset. However, new design form allows for its usability throughout the body and not just on a head.

X-Plus in Clinical Trials

In clinical trials, the X-Plus joined the Neuro RX Gamma in studies for Parkinson’s Disease therapy. It is also a primary contender for studies in developmental trauma disorder (DTD) and autism. Until the trials confirm otherwise, nobody should assume that the X-Plus is suitable to treat any of these diseases.

The new X-Plus has a price tag of USD $749. The initial roll-out should take place in January 2019. The first lot will ship to those who are eagerly awaiting on the waiting list. It should be available in the market place widely by February 2019.

Pre-ordering

If you’re interested in pre-ordering the X-Plus, please send an email to : info@vielight.com

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